SCHEMBL2818904

SCHEMBL2818904

C=CCNC(=O)C(Cl)(Cl)Cl

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
MAPT P10636 1/20 0.46
KMT2A Q03164 1/20 0.43
RAB9A P51151 1/20 0.41
HPGD P15428 6/20 0.40
ALDH1A1 P00352 3/20 0.40
CYP1A2 P05177 2/20 0.39
FAAH O00519 1/20 0.38
POLB P06746 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C19 P33261 1/20 0.37
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1574114 0.80 TSHR (0.42) TSHRSMN1; SMN2MAPTKMT2ARAB9A
SCHEMBL7599922 0.77 LMNA (0.39) TSHRSMN1; SMN2MAPTKMT2AALDH1A1
SCHEMBL236402 0.76 ALDH1A1 (0.50) TSHRSMN1; SMN2MAPTKMT2ARAB9A
SCHEMBL10818200 0.76 TSHR (0.46) TSHRSMN1; SMN2MAPTKMT2ARAB9A
SCHEMBL11232663 0.74 SMN1; SMN2 (0.37) TSHRSMN1; SMN2MAPTKMT2ARAB9A
SCHEMBL7627412 0.73 L3MBTL1 (0.32) LMNA
SCHEMBL12319214 0.73 SMN1; SMN2 (0.43) TSHRSMN1; SMN2MAPTKMT2ARAB9A
SCHEMBL7627409 0.73 L3MBTL1 (0.32) LMNA
SCHEMBL2408985 0.73 SMN1; SMN2 (0.43) TSHRSMN1; SMN2MAPTKMT2ARAB9A
SCHEMBL363871 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6639032-B2 Simple, environmentally friendly copolymerization of allyl monomers EASTMAN KODAK COMPANY 2003-10-28 US claimed
US-20030158357-A1 Highly branched polymer from telomerization EASTMAN KODAK COMPANY 2003-08-21 US claimed
CN-113816855-B Method for synthesizing chiral allyl carboxylic ester 常州大学 2022-09-27 CN disclosed
CN-113816855-A Method for synthesizing chiral allyl carboxylic ester 常州大学 2021-12-21 CN disclosed
US-20150321983-A1 A PROCESS FOR THE PREPARATION OF OSPEMIFENE FERMION OY (FI) 2015-11-12 US disclosed
EP-2909163-A1 A PROCESS FOR THE PREPARATION OF OSPEMIFENE Fermion Oy (FI) 2015-08-26 EP disclosed
WO-2014060640-A1 A PROCESS FOR THE PREPARATION OF OSPEMIFENE FERMION OY (FI) 2014-04-24 WO disclosed
US-20130035479-A1 FUNCTIONALIZED BETA 1,6 GLUCOSAMINE DISACCHARIDES AND PROCESS FOR THEIR PREPARATION OM PHARMA (CH) 2013-02-07 US disclosed
US-20100168054-A1 Functionalized Beta 1,6 Glucosamine Disaccharides and Process for Their Preparation OM PHARMA (CH) 2010-07-01 US disclosed
EP-2106403-A2 FUNCTIONALIZED BETA 1,6 GLUCOSAMINE DISACCHARIDES AND PROCESS FOR THEIR PREPARATION OM Pharma (CH) 2009-10-07 EP disclosed
WO-2008059307-A2 FUNCTIONALIZED BETA 1,6 GLUCOSAMINE DISACCHARIDES AND PROCESS FOR THEIR PREPARATION OM PHARMA (CH) 2008-05-22 WO disclosed
CN-1139925-A 'Delta' 12,13-iso-taxol analogs, antineoplastic use and pharmaceutical compositions containing them UPJOHN CO (US) 1997-01-08 CN disclosed
US-5565560-A TREATING AUTOIMMUNE DISEASES, PREVENTING TRANSPLANT REJECTION MERCK & CO., INC. (US) 1996-10-15 US disclosed
EP-0724570-A1 AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS G.D. SEARLE & CO. (US) 1996-08-07 EP disclosed
EP-0722448-A1 O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY MERCK & CO. INC. (US) 1996-07-24 EP disclosed
US-5532248-A O-aryl,O-alkyl, and O-alkenyl-macrolides having immunosuppressive activity MERCK CO., INC. (US) 1996-07-02 US disclosed
WO-1995034568-A1 ARYL, ALKYL, ALKENYL, AND ALKYNYLMACROLIDES MERCK & CO., INC. (US) 1995-12-21 WO disclosed
WO-1995011231-A1 AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS G. D. SEARLE & CO. (US) 1995-04-27 WO disclosed
WO-1995009857-A1 O-ARYL, O-ALKYL, O-ALKENYL AND O-ALKYNYL-MACROLIDES HAVING IMMUNOSUPPRESSIVE ACTIVITY MERCK & CO., INC. (US) 1995-04-13 WO disclosed
EP-0441218-A2 Anthracycline-glycosyl prodrugs, process for their preparation and their use in combination with functionalised tumour-specific enzyme conjugates BEHRINGWERKE Aktiengesellschaft (DE) 1991-08-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150321983-A1 A PROCESS FOR THE PREPARATION OF OSPEMIFENE CYP2F1, OGFR, OPRM1 TSHR 1266/4885SMN1; SMN2 859/4885MAPT 1435/4885
US-20130035479-A1 FUNCTIONALIZED BETA 1,6 GLUCOSAMINE DISACCHARIDES AND PROCESS FOR THEIR PREPARATION FUT6, FUT5, B3GNT2 TSHR 3844/4885SMN1; SMN2 3818/4885MAPT 4267/4885
US-20100168054-A1 Functionalized Beta 1,6 Glucosamine Disaccharides and Process for Their Preparation FUT6, FUT5, B3GNT2 TSHR 3844/4885SMN1; SMN2 3818/4885MAPT 4267/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.