Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GRM8 | O00222 | 4/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PTPRA | P18433 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9755057 | 0.96 | CYP1A2 (0.57) | CYP1A2GRM8GRM4ALDH1A1TDP1 | |
| SCHEMBL28064736 | 0.84 | CYP1A2 (0.45) | CYP1A2GRM8GRM4ALDH1A1TDP1 | |
| SCHEMBL31710991 | 0.84 | CYP1A2 (0.53) | CYP1A2GRM8GRM4PTPRA | |
| SCHEMBL1817774 | 0.83 | CYP1A2 (0.61) | CYP1A2GRM8GRM4ALDH1A1TDP1 | |
| SCHEMBL30959758 | 0.83 | CYP1A2 (0.61) | CYP1A2GRM8GRM4ALDH1A1TDP1 | |
| SCHEMBL1817775 | 0.83 | CYP1A2 (0.61) | CYP1A2GRM8GRM4ALDH1A1TDP1 | |
| SCHEMBL10891708 | 0.81 | CYP1A2 (0.64) | CYP1A2ALDH1A1TDP1 | |
| 2,4-Dinitrophenol SCHEMBL7081417 | 0.81 | ALDH1A1 (0.56) | GRM8GRM4ALDH1A1PTPRA | |
| SCHEMBL21518512 | 0.81 | GRM8 (0.63) | CYP1A2GRM8GRM4KMO | |
| SCHEMBL9116030 | 0.81 | GRM8 (0.63) | CYP1A2GRM8GRM4KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630555-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | DREXEL UNIVERSITY (US) | 2026-05-19 | — | — | US | disclosed |
| US-20240409544-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | DREXEL UNIVERSITY | 2024-12-12 | — | — | US | disclosed |
| US-12152036-B2 | Substituted pyrrolo[1,2-α]quinoxalin-4(5H)-ones as CX3CR1 antagonists | DREXEL UNIVERSITY (US) | 2024-11-26 | — | — | US | disclosed |
| CN-108220406-B | Method for detecting nucleic acid sequence variants | 生物概念股份有限公司 | 2022-09-30 | — | — | CN | disclosed |
| US-20220144845-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | UNIV DREXEL (US) | 2022-05-12 | — | — | US | disclosed |
| US-11267817-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | DREXEL UNIVERSITY (US) | 2022-03-08 | — | — | US | disclosed |
| CN-107523616-B | Assay for detecting genetic abnormalities in genomic nucleic acids | 奎斯特诊断投资公司 | 2021-05-25 | — | — | CN | disclosed |
| US-20200062768-A1 | CX3CR1 Small Molecule Antagonists, and Methods Using Same | DREXEL UNIVERSITY | 2020-02-27 | — | — | US | disclosed |
| US-20190316169-A1 | METHODS, COMPOSITIONS, AND KITS FOR DETECTING A CELL IN A SAMPLE | SONANUTECH INC. (US) | 2019-10-17 | — | — | US | disclosed |
| US-20190271693-A1 | METHODS, COMPOSITIONS, AND KITS FOR DETECTING BACTERIOPHAGE IN A SAMPLE | SONANUTECH INC. (US) | 2019-09-05 | — | — | US | disclosed |
| WO-2018098404-A1 | METHODS, COMPOSITIONS, AND KITS FOR DETECTING A CELL IN A SAMPLE | SONANUTECH INC. (US) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098402-A1 | METHODS, COMPOSITIONS, AND KITS FOR DETECTING BACTERIOPHAGE IN A SAMPLE | SONANUTECH INC. (US) | 2018-05-31 | — | — | WO | disclosed |
| CN-103635593-B | Method for detecting Nucleic acid sequence variants | 生物概念股份有限公司 | 2018-03-20 | — | — | CN | disclosed |
| CN-102574677-B | Silica nanoparticles incorporating chemiluminescent and absorbing active molecules | UNIV CORNELL | 2015-03-18 | — | — | CN | disclosed |
| WO-2010121066-A2 | SILICA NANOPARTICLES INCORPORATING CHEMILUMINESCENT AND ABSORBING ACTIVE MOLECULES | CORNELL RESEARCH FOUNDATION, INC. (US) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010071772-A2 | SYNTHESIS OF 3B-AMINO-5-CHOLESTENE AND RELATED 3B-HALIDES INVOLVING I-STEROID AND RETRO-I-STEROID REARRANGEMENTS | THE PENN STATE RESEARCH FOUNDATION (US) | 2010-06-24 | — | — | WO | disclosed |
| US-20100092470-A1 | ANTIBODIES, ANALOGS AND USES THEREOF | ICB INTERNATIONAL, INC. | 2010-04-15 | — | — | US | disclosed |
| WO-2010033913-A1 | ANTIBODIES, ANALOGS AND USES THEREOF | ICB INTERNATIONAL, INC. (US) | 2010-03-25 | — | — | WO | disclosed |
| US-7514400-B2 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2009-04-07 | — | — | US | disclosed |
| US-20060229235-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | THE PENN STATE RESEARCH FOUNDATION (US) | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240409544-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | CX3CR1, CCR5, CCL2 | CYP1A2 1744/4885GRM8 466/4885GRM4 218/4885 |
| US-20220144845-A1 | SUBSTITUTED PYRROLO[1,2-a]QUINOXALIN-4(5H)-ONES AS CX3CR1 ANTAGONISTS | CX3CR1, CCR5, CCL2 | CYP1A2 1744/4885GRM8 466/4885GRM4 218/4885 |
| US-20200062768-A1 | CX3CR1 Small Molecule Antagonists, and Methods Using Same | CX3CR1, CCR5, CXCR3 | CYP1A2 3478/4885GRM8 1024/4885GRM4 545/4885 |
| US-11267817-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | CX3CR1, CCR5, CCL2 | CYP1A2 1625/4885GRM8 511/4885GRM4 194/4885 |
| US-20060229235-A1 | Synthetic mimics of mammalian cell surface receptors: method and compositions | MSR1, M6PR, ASGR1 | CYP1A2 4713/4885GRM8 316/4885GRM4 384/4885 |
| US-12630555-B2 | Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists | CX3CR1, CCL2, CCR2 | CYP1A2 2851/4885GRM8 654/4885GRM4 404/4885 |
| US-12152036-B2 | Substituted pyrrolo[1,2-α]quinoxalin-4(5H)-ones as CX3CR1 antagonists | CX3CR1, CCR5, CCL2 | CYP1A2 1769/4885GRM8 451/4885GRM4 212/4885 |
| US-20100092470-A1 | ANTIBODIES, ANALOGS AND USES THEREOF | IGLV6-57, IGSF11, FCGR3B | CYP1A2 4855/4885GRM8 2723/4885GRM4 2121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.