SCHEMBL282876

SCHEMBL282876

Cc1nc2cccc([N+](=O)[O-])c2c(=O)o1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 10/20 0.62
KLK3 P07288 1/20 0.49
ALDH1A1 P00352 2/20 0.48
TYMS P04818 1/20 0.46
MEN1 O00255 4/20 0.45
KMT2A Q03164 4/20 0.45
MAPT P10636 2/20 0.45
F2 P00734 1/20 0.45
C1R P00736 1/20 0.45
TDP1 Q9NUW8 1/20 0.44
KDM4E B2RXH2 1/20 0.43
NPC1 O15118 1/20 0.43
TP53 P04637 1/20 0.43
GAA P10253 1/20 0.43
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
ALOX12 P18054 1/20 0.43
MPI P34949 1/20 0.43
HTT P42858 1/20 0.43
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15519149 0.90 ELANE (0.50) ELANEKLK3ALDH1A1TYMSMEN1
SCHEMBL10662992 0.81 ELANE (0.63) ELANEKLK3ALDH1A1TYMSMEN1
SCHEMBL5441389 0.80 ALDH1A1 (0.52) ELANEKLK3ALDH1A1MEN1KMT2A
SCHEMBL31489848 0.78 MEN1 (0.58) ELANEKLK3ALDH1A1MEN1KMT2A
SCHEMBL912480 0.78 KMT2A (0.73) ELANEKLK3ALDH1A1MEN1KMT2A
SCHEMBL17770598 0.78 MEN1 (0.58) ELANEKLK3ALDH1A1MEN1KMT2A
SCHEMBL26672077 0.77 TYMS (0.42) ELANEKLK3ALDH1A1TYMSMEN1
SCHEMBL282843 0.77 ELANE (1.00) ELANEC1R
SCHEMBL16213278 0.77 TDP1 (0.46) KLK3ALDH1A1TYMSMEN1KMT2A
SCHEMBL20423396 0.77 ELANE (0.64) ELANEKLK3ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2991976-B1 SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL) PIPERIDINE-2,6-DIONE CELGENE CORP (US) 2017-09-20 EP claimed
EP-2991976-A1 SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL) PIPERIDINE-2,6-DIONE Celgene Corporation (US) 2016-03-09 EP claimed
US-9266858-B2 Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione CELGENE CORPORATION (US) 2016-02-23 US claimed
US-20150274694-A1 SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2,6-DIONE CELGENE CORP (US) 2015-10-01 US claimed
US-20150203469-A1 ISOTOPOLOGUES OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL) PIPERIDINE-2-6-DIONE AND METHODS OF PREPARATION THEREOF CELGENE CORPORATION 2015-07-23 US claimed
EP-2892887-A1 ISOTOPOLOGUES OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL) PIPERIDINE-2-6-DIONE AND METHODS OF PREPARATION THEREOF Celgene Corporation (US) 2015-07-15 EP claimed
US-9067912-B2 Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,8-dione CELGENE CORPORATION (US) 2015-06-30 US claimed
US-20140330016-A1 SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2,6-DIONE CELGENE CORPORATION (US) 2014-11-06 US claimed
WO-2014179416-A1 SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL) PIPERIDINE-2,6-DIONE CELGENE CORPORATION (US) 2014-11-06 WO claimed
WO-2014039421-A1 ISOTOPOLOGUES OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL) PIPERIDINE-2-6-DIONE AND METHODS OF PREPARATION THEREOF CELGENE CORPORATION (US) 2014-03-13 WO claimed
US-12570626-B2 Degraders and degrons for targeted protein degradation C4 THERAPEUTICS, INC. (US) 2026-03-10 US disclosed
US-20250382240-A1 3-(5-SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTERO-PIPERIDINE-2,6-DIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME SALARIUS PHARMACEUTICALS INC (US) 2025-12-18 US disclosed
WO-2024220489-A1 DEUTERIUM-ENRICHED COMPOUND FOR USE IN A METHOD OF TREATMENT OF MULTIPLE MYELOMA SALARIUS PHARMACEUTICALS, INC. (US) 2024-10-24 WO disclosed
WO-2024148164-A1 SOLID FORMS AND METHODS OF USE SALARIUS PHARMACEUTICALS, INC (US) 2024-07-11 WO disclosed
US-11820720-B2 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deuteropiperidine-2,6-dione derivatives and compositions comprising and methods of using the same SALARIUS PHARMACEUTICALS, INC. (US) 2023-11-21 US disclosed
US-20100093774-A1 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME CELGENE CORPORATION. 2010-04-15 US disclosed
US-7635700-B2 e.g. 3-(5-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE; cytokine (epidermal/fibroblast/endothelial/tumor necrosis growth factors) antagonist; antitumor, antiinflammatory agent, neurodegenerative diseases CELGENE CORPORATION (US) 2009-12-22 US disclosed
EP-2066656-A2 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES AS ANTITUMOR AGENTS CELGENE CORPORATION (US) 2009-06-10 EP disclosed
US-20080161328-A1 e.g. 3-(5-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE; cytokine (epidermal/fibroblast/endothelial/tumor necrosis growth factors) antagonist; antitumor, antiinflammatory agent, neurodegenerative diseases CELGENE CORPORATION 2008-07-03 US disclosed
WO-2008039489-A2 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES AS ANTITUMOR AGENTS CELGENE CORPORATION (US) 2008-04-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150203469-A1 ISOTOPOLOGUES OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL) PIPERIDINE-2-6-DIONE AND METHODS OF PREPARATION THEREOF AQP3, CYP2D6, CYP3A5 ELANE 4693/4885KLK3 720/4885ALDH1A1 1628/4885
US-20140330016-A1 SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2,6-DIONE AZI2, DHPS, PKD2 ELANE 4613/4885KLK3 1951/4885ALDH1A1 1399/4885
US-20150274694-A1 SYNTHESIS OF 3-(5-AMINO-2-METHYL-4-OXOQUINAZOLIN-3(4H)-YL)PIPERIDINE-2,6-DIONE AZI2, DHPS, PKD2 ELANE 4613/4885KLK3 1951/4885ALDH1A1 1399/4885
US-11820720-B2 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deuteropiperidine-2,6-dione derivatives and compositions comprising and methods of using the same IL5, IL15, CXCR5 ELANE 1051/4885KLK3 139/4885ALDH1A1 2572/4885
US-12570626-B2 Degraders and degrons for targeted protein degradation ADRM1, UCHL3, USP30 ELANE 1337/4885KLK3 4514/4885ALDH1A1 3506/4885
US-20080161328-A1 e.g. 3-(5-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE; cytokine (epidermal/fibroblast/endothelial/tumor necrosis growth factors) antagonist; antitumor, antiinflammatory agent, neurodegenerative diseases FGF2, TNF, FGF1 ELANE 134/4885KLK3 2279/4885ALDH1A1 2470/4885
US-20250382240-A1 3-(5-SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTERO-PIPERIDINE-2,6-DIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME IL5, TLR5, IDO1 ELANE 1346/4885KLK3 139/4885ALDH1A1 1594/4885
US-20100093774-A1 5-SUBSTITUTED QUINAZOLINONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME IL5, IL6, PGF ELANE 1183/4885KLK3 2726/4885ALDH1A1 1085/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.