Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GABRP | O00591 | 1/20 | 0.50 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.50 |
| ▸ | GABRE | P78334 | 1/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253860 | 0.91 | RECQL (0.80) | RECQLALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL333313 | 0.88 | RECQL (1.00) | RECQLALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL29516764 | 0.88 | RECQL (1.00) | RECQLALDH1A1KDM4ENPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8835389 | 0.86 | RECQL (0.97) | RECQLALDH1A1KDM4ENPC1RAB9A | |
| Hydrazine SCHEMBL11776632 | 0.86 | RECQL (0.97) | RECQLALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL3050631 | 0.86 | RECQL (0.73) | RECQLALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL11842389 | 0.85 | RECQL (0.77) | RECQLALDH1A1TP53MAPTGABRP | |
| SCHEMBL4707059 | 0.83 | RECQL (0.73) | RECQLALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL31272816 | 0.83 | RECQL (0.73) | RECQLALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9540049 | 0.83 | RECQL (0.79) | RECQLALDH1A1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377588-B1 | 4-BETA-1''-[(2''-(SUBSTITUTED BENZOYL)ANILINO] PODOPHYLLOTOXIN ANALOGUES USEFUL AS ANTICANCER AGENTS | COUNCIL SCIENT IND RES (IN) | 2005-08-10 | — | — | EP | claimed |
| US-20050101804-A1 | 4Beta-1\"-{2'-substituted benzoyl) anilino] podophyllotoxin analogues useful as anticancer agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2005-05-12 | — | — | US | claimed |
| EP-1377588-A1 | 4-BETA-1''-[(2''-(SUBSTITUTED BENZOYL)ANILINO] PODOPHYLLOTOXIN ANALOGUES USEFUL AS ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-01-07 | — | — | EP | claimed |
| WO-2003082876-A1 | 4-BETA-1''-`(2''-(SUBSTITUTED BENZOYL)ANILINO! PODOPHYLLOTOXIN ANALOGUES USEFUL AS ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-10-09 | — | — | WO | claimed |
| US-7781441-B2 | (3,4-dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amine | HOFFMANN-LA ROCHE INC. (US) | 2010-08-24 | — | — | US | disclosed |
| EP-1888538-B1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-(2-ARYLOXY-ETHYL)-AMINES HAVING AN ACTIVITY ON THE 5-HT RECEPTOR | HOFFMANN LA ROCHE (CH) | 2009-11-18 | — | — | EP | disclosed |
| US-7348332-B2 | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines | HOFFMANN-LA ROCHSE INC. (US) | 2008-03-25 | — | — | US | disclosed |
| EP-1888538-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-(2-ARYLOXY-ETHYL)-AMINES HAVING AN ACTIVITY ON THE 5-HT RECEPTOR | F. Hoffmann-Roche AG (CH) | 2008-02-20 | — | — | EP | disclosed |
| EP-1871748-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-INDAN-1-YL-AMINES | F. Hoffmann-Roche AG (CH) | 2008-01-02 | — | — | EP | disclosed |
| US-20060252779-A1 | (3,4-Dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amine | HOFFMANN-LA ROCHE INC. | 2006-11-09 | — | — | US | disclosed |
| WO-2006117305-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-(2-ARYLOXY-ETHYL)-AMINES HAVING AN ACTIVITY ON THE 5-HT RECEPTOR | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-09 | — | — | WO | disclosed |
| WO-2006108773-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-INDAN-1-YL-AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-10-19 | — | — | WO | disclosed |
| US-20060229323-A1 | (3,4-Dihydro-quinazolin-2-yl)-indan-1-yl-amines | F. HOFFMANN-LA ROCHE AG (CH) | 2006-10-12 | — | — | US | disclosed |
| EP-1377588-B1 | 4-BETA-1''-[(2''-(SUBSTITUTED BENZOYL)ANILINO] PODOPHYLLOTOXIN ANALOGUES USEFUL AS ANTICANCER AGENTS | COUNCIL SCIENT IND RES (IN) | 2005-08-10 | — | — | EP | disclosed |
| EP-1377588-A1 | 4-BETA-1''-[(2''-(SUBSTITUTED BENZOYL)ANILINO] PODOPHYLLOTOXIN ANALOGUES USEFUL AS ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-01-07 | — | — | EP | disclosed |
| WO-2003082876-A1 | 4-BETA-1''-`(2''-(SUBSTITUTED BENZOYL)ANILINO! PODOPHYLLOTOXIN ANALOGUES USEFUL AS ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229323-A1 | (3,4-Dihydro-quinazolin-2-yl)-indan-1-yl-amines | HTR5A, HTR1A, HTR1E | RECQL 2155/4885ALDH1A1 281/4885KDM4E 928/4885 |
| US-20060252779-A1 | (3,4-Dihydro-quinazolin-2-yl)-(2-aryloxy-ethyl)-amine | HTR5A, NPY5R, HTR3A | RECQL 1301/4885ALDH1A1 780/4885KDM4E 1735/4885 |
| US-20050101804-A1 | 4Beta-1\"-{2'-substituted benzoyl) anilino] podophyllotoxin analogues useful as anticancer agents | TUBB4A, CASP4, TUBB4B | RECQL 1648/4885ALDH1A1 1082/4885KDM4E 622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.