Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20002727 | 0.77 | MMP8 (0.41) | L3MBTL1KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL28297780 | 0.76 | NPC1 (0.35) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL27829606 | 0.75 | MMP8 (0.50) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL28331075 | 0.75 | MMP8 (0.50) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL28332593 | 0.73 | MME (0.40) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL21527822 | 0.71 | ALDH1A1 (0.41) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| SCHEMBL21527820 | 0.71 | ALDH1A1 (0.41) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| SCHEMBL28707321 | 0.69 | CES2 (0.32) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL3393064 | 0.68 | L3MBTL1 (0.43) | MAPTCRHBPCRHR2L3MBTL1KMT2A | |
| SCHEMBL7494802 | 0.67 | NLRP3 (0.42) | MAPTL3MBTL1KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715633-A | Dopamine-B-hydroxylase inhibitors | 巴尔-波特拉及康邦亚股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-109715155-A | blood brain barrier-penetrating agent dopamine- β -hydroxylase inhibitors | 巴尔-波特拉及康邦亚股份有限公司 | 2019-05-03 | — | — | CN | disclosed |