Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CCR6 | P51684 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850071 | 0.89 | MEN1 (0.47) | SMN1; SMN2ALDH1A1MAPTTSHRRAB9A | |
| SCHEMBL2853837 | 0.81 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1MAPTHPGDHTT | |
| SCHEMBL14498665 | 0.69 | RAB9A (0.57) | SMN1; SMN2ALDH1A1MAPTHPGDTSHR | |
| SCHEMBL1030263 | 0.69 | LMNA (0.74) | SMN1; SMN2ALDH1A1MAPTHTTRAB9A | |
| SCHEMBL4407371 | 0.67 | ALDH1A1 (0.79) | SMN1; SMN2ALDH1A1MAPTHPGDHTT | |
| SCHEMBL2006114 | 0.67 | ALDH1A1 (1.00) | SMN1; SMN2ALDH1A1MAPTHPGDHTT | |
| SCHEMBL24210095 | 0.67 | TSHR (0.85) | SMN1; SMN2ALDH1A1MAPTTSHRPOLB | |
| SCHEMBL2226280 | 0.66 | PDK1 (0.72) | SMN1; SMN2ALDH1A1MAPTHTTL3MBTL1 | |
| SCHEMBL6348512 | 0.66 | PDK1 (0.72) | SMN1; SMN2ALDH1A1MAPTHTTRAB9A | |
| SCHEMBL2093161 | 0.66 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1MAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130509-A1 | NOVEL ANTIBIOTICS | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWE- TENSCHAPPELIJK ONDERZOEK TNO (NL) | 2010-05-27 | — | — | US | claimed |
| EP-1978021-A1 | Novel antibiotics | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO (NL) | 2008-10-08 | — | — | EP | claimed |
| US-20100130509-A1 | NOVEL ANTIBIOTICS | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWE- TENSCHAPPELIJK ONDERZOEK TNO (NL) | 2010-05-27 | — | — | US | disclosed |
| EP-1978021-A1 | Novel antibiotics | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO (NL) | 2008-10-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130509-A1 | NOVEL ANTIBIOTICS | TMEM165, LAS1L, RPS2 | SMN1; SMN2 4435/4885ALDH1A1 4431/4885MAPT 2857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.