Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 4/20 | 0.37 |
| ▸ | DRD5 | P21918 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 8/20 | 0.35 |
| ▸ | HTR2A | P28223 | 7/20 | 0.35 |
| ▸ | HRH1 | P35367 | 4/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 7/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2841048 | 0.88 | HTR2C (0.35) | DRD1DRD5HTR2CHTR2AHRH1 | |
| SCHEMBL2836825 | 0.82 | SLC6A2 (0.35) | HRH1HRH4PNMT | |
| Hydrochloric Acid SCHEMBL2842809 | 0.80 | DRD1 (0.34) | DRD1DRD5HTR2CHTR2AHTR2B | |
| SCHEMBL2840148 | 0.78 | DRD1 (0.41) | DRD1DRD5HTR2CHTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL2844305 | 0.76 | PNMT (0.39) | HTR2CHTR2AHRH1HRH4HTR2B | |
| SCHEMBL2836074 | 0.72 | PKM (0.32) | — | |
| SCHEMBL2837042 | 0.72 | SIGMAR1 (0.36) | DRD1DRD5 | |
| SCHEMBL3583019 | 0.71 | SLC6A2 (0.47) | HTR2CHTR2AHTR2B | |
| SCHEMBL2837709 | 0.69 | TOP2A (0.36) | HTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL3575016 | 0.68 | GID4 (0.38) | DRD1DRD5HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | DRD1 40/4885DRD5 287/4885HTR2C 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.