Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27832009 | 1.00 | PPARA (0.46) | PPARATSHRTP53EGLN1EGLN3 | |
| Acrylic Acid SCHEMBL31397813 | 0.88 | LMNA (0.48) | PPARATSHRTRPA1BLMTDP1 | |
| Bicarbonate SCHEMBL980471 | 0.88 | TRPA1 (0.43) | PPARATSHRTRPA1BLMTDP1 | |
| Oxalic Acid SCHEMBL27702626 | 0.86 | TRPA1 (0.42) | PPARATSHRTRPA1BLMTDP1 | |
| Succinic Acid SCHEMBL27919584 | 0.82 | ALDH1A1 (0.47) | PPARAEGLN1TRPA1BLMTDP1 | |
| Bicarbonate SCHEMBL27485028 | 0.82 | TRPA1 (0.39) | PPARATSHRTRPA1ALDH1A1OXER1 | |
| Pyruvate SCHEMBL3626124 | 0.82 | TRPA1 (0.39) | PPARATSHRTRPA1ALDH1A1OXER1 | |
| Pyruvate SCHEMBL3626126 | 0.82 | TRPA1 (0.39) | PPARATSHRTRPA1ALDH1A1OXER1 | |
| Butadiene SCHEMBL16290286 | 0.81 | TSHR (0.44) | PPARATSHRTP53EGLN1EGLN3 | |
| Urea SCHEMBL27773384 | 0.81 | TRPA1 (0.42) | PPARATSHRTP53TRPA1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111718532-B | Resin composition, coated cable, and wire harness | 矢崎总业株式会社 | 2022-11-18 | — | — | CN | disclosed |
| CN-111718532-A | Resin composition, coated cable, and wire harness | 矢崎总业株式会社 | 2020-09-29 | — | — | CN | disclosed |