Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | ITGA1 | P56199 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28506242 | 0.88 | MEN1 (0.79) | MEN1KMT2AMAPTHTR6HPGD | |
| SCHEMBL2029062 | 0.88 | ITGA1 (0.68) | MEN1KMT2AITGA1LMNAMAPT | |
| SCHEMBL30737482 | 0.85 | MEN1 (0.65) | MEN1KMT2AITGA1HTR6POLB | |
| SCHEMBL28271817 | 0.85 | MEN1 (0.65) | MEN1KMT2AITGA1HTR6POLB | |
| SCHEMBL28121241 | 0.83 | MAPT (0.63) | MEN1KMT2AITGA1LMNAMAPT | |
| SCHEMBL7577795 | 0.83 | ITGA1 (0.74) | MEN1KMT2AITGA1LMNAMAPT | |
| SCHEMBL28513321 | 0.81 | MEN1 (0.59) | MEN1KMT2ALMNAHTR6HPGD | |
| SCHEMBL30737524 | 0.80 | HTR6 (0.79) | MEN1KMT2AHTR6CYP19A1POLB | |
| SCHEMBL28271815 | 0.80 | HTR6 (0.79) | MEN1KMT2AHTR6CYP19A1POLB | |
| SCHEMBL9616631 | 0.80 | WDR5 (0.67) | MEN1KMT2AITGA1HTR6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109081793-B | Sulfonamide urease inhibitor and preparation method and application thereof | 吉首大学 | 2021-03-30 | — | — | CN | disclosed |
| CN-109096156-B | Disulfonyl meta-aryl diamine urease inhibitor and preparation method and application thereof | 吉首大学 | 2021-01-15 | — | — | CN | disclosed |