Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.51 |
| ▸ | GRK2 | P25098 | 4/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854358 | 0.85 | VNN1 (0.63) | SMN1; SMN2NAMPTVNN1GAAALDH1A1 | |
| SCHEMBL2850048 | 0.82 | LMNA (0.47) | GRK2LMNAVNN1GAAALDH1A1 | |
| SCHEMBL4983660 | 0.80 | KDR (0.66) | NAMPT | |
| SCHEMBL2862664 | 0.77 | MAOA (0.58) | PIP4K2CSMN1; SMN2VNN1GAAALDH1A1 | |
| SCHEMBL2857028 | 0.77 | INSR (0.49) | GAAALDH1A1MAPTHSD17B10 | |
| SCHEMBL3715900 | 0.76 | CA12 (0.46) | GRK2LMNASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL632566 | 0.75 | ADRA1A (0.59) | — | |
| SCHEMBL18893560 | 0.73 | CA1 (0.43) | GRK2LMNASMN1; SMN2PTGS2ALDH1A1 | |
| SCHEMBL5998792 | 0.73 | FLT1 (0.55) | GRK2GAAALDH1A1KDM4EPOLB | |
| SCHEMBL6000282 | 0.73 | ROCK2 (0.60) | GRK2ROCK2SMN1; SMN2NAMPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |