Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850809 | 0.93 | MAPT (0.43) | MAPK14MAPTTRPC1TRPC3STIM1 | |
| SCHEMBL2852353 | 0.92 | RAB9A (0.44) | MAPK14MAPTTRPC1TRPC3STIM1 | |
| SCHEMBL2850337 | 0.89 | MAPT (0.40) | MAPTTDP1NPBWR1MCHR1SMN1; SMN2 | |
| SCHEMBL2858182 | 0.88 | P2RX7 (0.44) | P2RX7MAPTRAB9ANPSR1 | |
| SCHEMBL2859508 | 0.87 | CYP1A2 (0.46) | MAPTTDP1TRPC1TRPC3STIM1 | |
| SCHEMBL2853465 | 0.86 | RAB9A (0.44) | MAPTTDP1TRPC1TRPC3STIM1 | |
| SCHEMBL2857582 | 0.84 | MAPT (0.42) | P2RX7MAPTTRPC1TRPC3STIM1 | |
| SCHEMBL2852361 | 0.84 | KDM4E (0.47) | P2RX7MAPK14MAPTTDP1TRPC1 | |
| SCHEMBL2858283 | 0.83 | MAPT (0.43) | P2RX7MAPTTRPC1TRPC3STIM1 | |
| SCHEMBL2854533 | 0.83 | MEN1 (0.46) | P2RX7MAPTTRPC1TRPC3STIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |