Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2860400 | 0.90 | RAB9A (0.53) | NPC1RAB9APKMNR3C1NPBWR1 | |
| SCHEMBL2850131 | 0.89 | RAB9A (0.61) | NPC1RAB9APKMMAPTSMN1; SMN2 | |
| SCHEMBL2848335 | 0.87 | ATM (0.54) | NPC1RAB9APKMATMNR3C1 | |
| SCHEMBL2857558 | 0.87 | NPC1 (0.50) | NPC1RAB9APKMATMMAPT | |
| SCHEMBL2853093 | 0.87 | NPC1 (0.52) | NPC1RAB9APKMATMNR3C1 | |
| SCHEMBL2858533 | 0.85 | ATM (0.47) | NPC1RAB9APKMATMNR3C1 | |
| SCHEMBL2854531 | 0.84 | LMNA (0.52) | NPC1RAB9ANR3C1MAPTNPBWR1 | |
| SCHEMBL2852417 | 0.83 | MAPT (0.49) | NPC1RAB9APKMMAPTNPBWR1 | |
| SCHEMBL2861643 | 0.82 | CNR1 (0.50) | NPC1RAB9AATMSMN1; SMN2CNR1 | |
| SCHEMBL2855794 | 0.79 | RAB9A (0.48) | NPC1RAB9APKMMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |