Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 3/20 | 0.52 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.41 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL330960 | 1.00 | CA1 (0.52) | CA1FOLH1BBOX1GRM8GRM6 | |
| D-Glutamate SCHEMBL330961 | 1.00 | CA1 (0.52) | CA1FOLH1BBOX1GRM8GRM6 | |
| D-Glutamate SCHEMBL18880 | 1.00 | CA1 (0.52) | CA1FOLH1BBOX1GRM8GRM6 | |
| D-Glutamate SCHEMBL16335 | 1.00 | CA1 (0.52) | CA1FOLH1BBOX1GRM8GRM6 | |
| D-Glutamate SCHEMBL16053546 | 0.98 | CA1 (0.50) | CA1FOLH1BBOX1GRM8GRM6 | |
| D-Glutamate SCHEMBL8853445 | 0.98 | CA1 (0.50) | CA1FOLH1BBOX1GRM8GRM6 | |
| D-Glutamate SCHEMBL1518007 | 0.98 | CA1 (0.50) | CA1FOLH1BBOX1GRM8GRM6 | |
| D-Glutamate SCHEMBL317909 | 0.98 | CA1 (0.50) | CA1FOLH1BBOX1GRM8GRM6 | |
| D-Glutamate SCHEMBL1897914 | 0.98 | CA1 (0.50) | CA1FOLH1BBOX1GRM8GRM6 | |
| D-Glutamate SCHEMBL2853212 | 0.98 | CA1 (0.50) | CA1FOLH1BBOX1GRM8GRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110060046-A1 | AGENT AND FOOD FOR PREVENTING/IMPROVING FUNCTIONAL DIGESTIVE DISORDER | AJINOMOTO CO. INC. (JP) | 2011-03-10 | — | — | US | claimed |
| CN-117142970-A | Method of forming a chelating composition | 诺力昂化学品国际有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-117142972-A | Method of forming a chelating composition | 诺力昂化学品国际有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-117142969-A | Chelating compositions and methods of forming the same | 诺力昂化学品国际有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-116670326-A | Copper component | 纳美仕有限公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-109569476-B | Method for preparing biomass oil from freshwater fish waste | 浙江海洋大学 | 2023-07-04 | — | — | CN | disclosed |
| CN-114246823-A | Ointment for treating oral ulcer and preparation method thereof | 江苏罗来雅实业股份有限公司 | 2022-03-29 | — | — | CN | disclosed |
| US-10676626-B2 | Ink jet textile printing ink composition and ink receiving container | SEIKO EPSON CORPORATION (JP) | 2020-06-09 | — | — | US | disclosed |
| EP-3299426-B1 | INK JET TEXTILE PRINTING INK COMPOSITION AND INK RECEIVING CONTAINER | SEIKO EPSON CORP (JP) | 2019-07-10 | — | — | EP | disclosed |
| EP-3463295-A1 | COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION, COMPRISING HUMAN GLUCAGON AND AN END-GRAFTED COPOLYAMINO ACID | Adocia (FR) | 2019-04-10 | — | — | EP | disclosed |
| US-5631240-A | KETONE | BIORESEARCH, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5631295-A | 2-(4-METHOXYPHENOXY)PROPIONIC ACID, TAURINE, ASPARTYLPHENYL ALANINE, ASPARTYLTYROSINE AND DIHYDROXYBENZOIC ACID | BIORESEARCH, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5631294-A | PHENOXY- OR PHENYL-ALKANOIC ACIDS | BIORESEARCH, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5631038-A | COMPOUNDS (TASTANDS) TO REDUCE OR ELIMINATE A BITTER OR METALLIC TASTE ARE ADDED TO FOODS CONTAINING SODIUM CHLORIDE | BIORESEARCH, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5631299-A | TAURINE OR AN ACCEPTABLE SALT (A TASTAND) TO REDUCE OR ELIMINATE A BITTER OR METALLIC TASTE; FOODS; DRUGS; SWEETENERS; POTASSIUM CHLORIDE | BIORESEARCH, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5631292-A | COMPOUNDS TO REMOVE BITTER TASTES FROM FOOD | BIORESEARCH, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5631252-A | Specific eatable taste modifiers | BIORESEARCH, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5631231-A | COMPOUNDS (TASTANDS, E.G., DIPEPTIDES) TO REDUCE OR ELIMINATE A BITTER OR METALLIC TASTE; FOODS; DRUGS; SWEETENERS; POTASSIUM CHLORIDE | BIORESEARCH, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5631272-A | SUBSTITUTED TRYPTAMINES | BIORESEARCH, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-3985722-A | Process for preparing N-higher aliphatic acyl derivatives of amino acids, peptides or proteins | AJINOMOTO CO., INC. (JA) | 1976-10-12 | — | — | US | disclosed |