Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858680 | 0.91 | NPC1 (0.45) | TP53P2RX7KMT2AABCB11MAPT | |
| SCHEMBL2854704 | 0.90 | P2RX7 (0.48) | TP53P2RX7MEN1KMT2AHPGD | |
| SCHEMBL2861634 | 0.89 | RAB9A (0.44) | TP53HPGDMAPTMAPK1 | |
| SCHEMBL2858097 | 0.89 | P2RX7 (0.53) | TP53P2RX7HPGDMAPT | |
| SCHEMBL2852350 | 0.85 | NPC1 (0.53) | TP53HPGDMAPTMAPK1 | |
| SCHEMBL2859872 | 0.85 | TAAR1 (0.54) | TP53MEN1KMT2AHPGD | |
| SCHEMBL2856697 | 0.85 | KDM4E (0.46) | RIPK1TP53P2RX7HIF1AABCB11 | |
| SCHEMBL2857276 | 0.83 | RAB9A (0.47) | TP53P2RX7HPGDMAPTMAPK1 | |
| SCHEMBL2850369 | 0.81 | P2RX7 (0.56) | TP53P2RX7MAPT | |
| SCHEMBL2858580 | 0.81 | HIF1A (0.43) | TP53P2RX7HIF1AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |