Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.33 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAP2 | P11137 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28529302 | 0.80 | EPAS1 (0.37) | ACLYGRIA1CACNG8ALDH1A1LMNA | |
| SCHEMBL14744335 | 0.77 | GRIA1 (0.39) | ACLYGRIA1CACNG8L3MBTL1GRIN2B | |
| SCHEMBL4379379 | 0.74 | L3MBTL1 (0.36) | ACLYGRIA1CACNG8L3MBTL1SCN9A | |
| SCHEMBL28535038 | 0.72 | POLB (0.33) | L3MBTL1KDM4EALDH1A1LMNAGLA | |
| SCHEMBL28929835 | 0.69 | HSD17B10 (0.46) | ACLYL3MBTL1SCN9AKDM4EHSP90AA1 | |
| SCHEMBL7396451 | 0.69 | MAPT (0.47) | ACLYSCN9AKDM4EHSP90AA1ALDH1A1 | |
| SCHEMBL14746409 | 0.68 | RORC (0.40) | ACLYGRIA1CACNG8RORCCYP2C9 | |
| SCHEMBL14746790 | 0.67 | ALDH1A1 (0.38) | L3MBTL1SCN9AKDM4EALDH1A1LMNA | |
| SCHEMBL7937713 | 0.66 | MPL (0.40) | GRIA1CACNG8L3MBTL1GRIN2BKDM4E | |
| SCHEMBL31120353 | 0.66 | SCN9A (0.44) | L3MBTL1SCN9AKDM4EALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107635970-B | Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators | 詹森药业有限公司 | 2021-03-12 | — | — | CN | disclosed |