Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | ACR | P10323 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489203 | 0.89 | KMT2A (0.60) | CES2CES1LMNAMEN1KMT2A | |
| SCHEMBL13719843 | 0.84 | LMNA (0.63) | LMNAMEN1KMT2AKDM4EACHE | |
| SCHEMBL30463307 | 0.83 | CES2 (0.59) | CES2CES1LMNAPARP1ESR1 | |
| SCHEMBL8048513 | 0.83 | CES2 (0.59) | CES2CES1LMNAPARP1ESR1 | |
| SCHEMBL9671480 | 0.82 | CES2 (0.57) | CES2CES1LMNAPARP1ESR1 | |
| SCHEMBL5700480 | 0.82 | CES2 (0.57) | CES2CES1LMNAPARP1ESR1 | |
| SCHEMBL16520280 | 0.82 | KMT2A (0.52) | CES2CES1LMNAMEN1KMT2A | |
| SCHEMBL9671485 | 0.82 | LMNA (0.59) | CES2CES1LMNAPARP1ESR1 | |
| SCHEMBL361383 | 0.82 | LMNA (0.66) | CES2CES1LMNAPARP1ESR1 | |
| SCHEMBL3955745 | 0.80 | MEN1 (0.80) | CES2CES1LMNAPARP1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015656-A | TABULAR SILICA DISPERSION OBTAINED BY MIXING TABULAR SILICA, GELATIN, CYCLODEXTRIN, COMPOUND CAPABLE OF CROSSLINKING GELATIN | KONICA CORPORATION (JP) | 2000-01-18 | — | — | US | claimed |
| EP-2995617-B1 | BENZOISOTHIAZOLE COMPOUNDS AND USE IN PREPARATION OF ANTIPSYCHOTIC DRUGS | SHANGHAI INST PHARMACEUTICAL IND (CN) | 2018-01-31 | — | — | EP | disclosed |
| US-9550741-B2 | Benzoisothiazole compounds and methods of treating schizophrenia | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2017-01-24 | — | — | US | disclosed |
| US-20160096811-A1 | BENZOISOTHIAZOLE COMPOUNDS AND USE IN PREPARATION OF ANTIPSYCHOTIC DRUGS | SHANAGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2016-04-07 | — | — | US | disclosed |
| CN-105431422-A | Isoindoline or isoquinoline compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB | 2016-03-23 | — | — | CN | disclosed |
| EP-2995617-A1 | BENZOISOTHIAZOLE COMPOUNDS AND USE IN PREPARATION OF ANTIPSYCHOTIC DRUGS | Shanghai Institute of Pharmaceutical Industry (CN) | 2016-03-16 | — | — | EP | disclosed |
| EP-1809653-B1 | SUBSTITUTED NONADEPSIPEPTIDES | AICURIS GMBH & CO KG (DE) | 2010-01-20 | — | — | EP | disclosed |
| US-7579479-B2 | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| EP-1218361-B1 | OXA- AND THIAZOLE DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1939188-A1 | Oxa-and thiazole derivatives useful as antidiabetic and antiobesity agents | Bristol-Myers Squibb Company (US) | 2008-07-02 | — | — | EP | disclosed |
| US-5486514-A | GASTRIN, CHOLECYSTOKININ RECEPTOR ANTAGONISTS | GLAXO SPA (IT) | 1996-01-23 | — | — | US | disclosed |
| EP-0648740-A1 | AMINO ACID AMIDE DERIVATIVE, AGROHORTICULTURAL BACTERICIDE, AND PRODUCTION PROCESS | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1995-04-19 | — | — | EP | disclosed |
| EP-0444325-B1 | Modified dextran binder for use in thermal dye transfer | AGFA GEVAERT NV (BE) | 1994-12-07 | — | — | EP | disclosed |
| EP-0623118-A1 | CARBAMATE DERIVATIVES AND THEIR USE IN MEDICINE | GLAXO S.p.A. (IT) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993014075-A1 | CARBAMATE DERIVATIVES AND THEIR USE IN MEDICINE | GLAXO SPA (IT) | 1993-07-22 | — | — | WO | disclosed |
| US-5151405-A | Multilayer element of a support and a modified dextran binder | AGFA-GEVAERT, N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| EP-0444325-A1 | Modified dextran binder for use in thermal dye transfer | AGFA-GEVAERT N.V. (BE) | 1991-09-04 | — | — | EP | disclosed |
| EP-0275583-B1 | PHOTOGRAPHIC PROTEINACEOUS LAYERS COMPRISING DEXTRAN DERIVATIVES | AGFA-GEVAERT N.V. (BE) | 1991-03-06 | — | — | EP | disclosed |
| US-4879209-A | CHLOROFORMATE REACTION PRODUCT FOR HARDENING | AGFA-GEVAERT, N.V. (BE) | 1989-11-07 | — | — | US | disclosed |
| EP-0275583-A2 | Photographic proteinaceous layers comprising dextran derivatives | AGFA-GEVAERT N.V. (BE) | 1988-07-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160096811-A1 | BENZOISOTHIAZOLE COMPOUNDS AND USE IN PREPARATION OF ANTIPSYCHOTIC DRUGS | HTR3A, SLC6A3, HTR5A | CES2 4045/4885CES1 4053/4885LMNA 3956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.