Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852552 | 0.93 | MEN1 (0.51) | P2RX7MEN1KMT2AMAPTPOLB | |
| SCHEMBL2860786 | 0.93 | MAPT (0.49) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL2852361 | 0.88 | KDM4E (0.47) | P2RX7MEN1KMT2AMAPTPOLB | |
| SCHEMBL2860986 | 0.88 | MAPT (0.45) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL2848541 | 0.85 | RAB9A (0.43) | P2RX7MEN1KMT2AMAPTPOLB | |
| SCHEMBL2855775 | 0.84 | P2RY1 (0.44) | P2RX7MEN1KMT2AMAPTPOLB | |
| SCHEMBL2854596 | 0.83 | TP53 (0.46) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL2858155 | 0.83 | POLB (0.49) | P2RX7MAPTPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL2854563 | 0.83 | P2RX7 (0.57) | P2RX7MAPTPOLBSMN1; SMN2KDM4E | |
| SCHEMBL2850871 | 0.83 | NPC1 (0.51) | KMT2AMAPTPOLBSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |