Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28597653 | 0.86 | HTR1A (0.55) | KMT2AABCB1DRD2HTR1AHTR2A | |
| SCHEMBL2764499 | 0.85 | PNMT (0.50) | KMT2AMEN1RAB9AHTR1AHRH1 | |
| SCHEMBL28585852 | 0.84 | ALDH1A1 (0.50) | KMT2AMEN1TSHRDRD2ALOX15 | |
| SCHEMBL28597583 | 0.83 | PDE4B (0.45) | KMT2AMEN1TSHRDRD2HRH1 | |
| SCHEMBL698769 | 0.80 | KDM4E (0.49) | KMT2AMEN1TNFRAB9ANOD2 | |
| SCHEMBL697563 | 0.79 | SIGMAR1 (0.50) | KMT2AMEN1RAB9AHTR1AHRH1 | |
| SCHEMBL28595960 | 0.77 | DHFR (0.50) | KMT2AMEN1MAPK1DRD2DRD3 | |
| SCHEMBL6534071 | 0.77 | KMT2A (0.43) | KMT2AABCB1MAPK1DRD2KCNH2 | |
| SCHEMBL7623631 | 0.76 | TMEM97 (0.51) | KMT2AABCB1MEN1TNFNOD2 | |
| SCHEMBL28596092 | 0.76 | DRD2 (0.44) | KMT2AMEN1TSHRDRD2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166139-A | Pyrrolo [2,3-b ] pyridines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-07-23 | — | — | CN | disclosed |