Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Letestuianin C SCHEMBL4410123 | 0.90 | F2RL1 (0.60) | MMP12HDAC2HDAC8TRPV1CA2 | |
| SCHEMBL10755024 | 0.89 | TRPV1 (0.55) | MMP12HDAC2HDAC8TRPV1CA2 | |
| SCHEMBL13311578 | 0.86 | TRPV1 (0.64) | MMP12HDAC2HDAC8TRPV1F2RL1 | |
| SCHEMBL8108885 | 0.85 | ESR1 (0.62) | HDAC2HDAC8TRPV1CA2CAMK2A | |
| SCHEMBL1532408 | 0.83 | MMP12 (0.79) | MMP12HDAC2HDAC8ALDH1A1MAPT | |
| Hydroxyphenyl Propionic Acid SCHEMBL35486 | 0.83 | FFAR1 (0.68) | HDAC2HDAC8TRPV1CA2CAMK2A | |
| SCHEMBL5643123 | 0.82 | MMP12 (0.66) | MMP12F2RL1KDM4EALDH1A1LMNA | |
| SCHEMBL7508200 | 0.82 | MMP12 (0.66) | MMP12F2RL1MEN1ALDH1A1GAA | |
| SCHEMBL1645396 | 0.82 | KDM4E (0.55) | MMP12HDAC2HDAC8TRPV1ESR1 | |
| Hydroxyphenyl Propionic Acid SCHEMBL5606896 | 0.81 | FFAR1 (0.65) | HDAC2HDAC8TRPV1CA2CAMK2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738605-B2 | Hybrid compounds of curcumin and melatonin as neuroprotectants for neurodegenerative disorders | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2017-08-22 | — | — | US | claimed |
| US-20160289187-A1 | HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2016-10-06 | — | — | US | claimed |
| WO-2015069970-A1 | HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2015-05-14 | — | — | WO | claimed |
| US-9738605-B2 | Hybrid compounds of curcumin and melatonin as neuroprotectants for neurodegenerative disorders | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2017-08-22 | — | — | US | disclosed |
| US-20160289187-A1 | HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2016-10-06 | — | — | US | disclosed |
| WO-2015069970-A1 | HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2015-05-14 | — | — | WO | disclosed |
| EP-2195323-B1 | Polyspirane compounds, use thereof in the treatment of malaria or toxoplasmosis and method for their preparation | UNIV JOSEPH FOURIER (FR) | 2011-12-28 | — | — | EP | disclosed |
| EP-2195323-A2 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | Université Joseph Fourier (FR) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009077677-A2 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2009-06-25 | — | — | WO | disclosed |
| US-4672071-A | Antihypertensive dihydropyridine compositions, optical isomers and intermediates | SYNTEX (U.S.A.) INC. (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0191448-A2 | Antihypertensive dihydropyridine derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-08-20 | — | — | EP | disclosed |
| US-4595690-A | Hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1986-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160289187-A1 | HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS | MTNR1A, MTNR1B, HTT | MMP12 1872/4885HDAC2 313/4885HDAC8 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.