Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 10/20 | 0.49 |
| ▸ | CA2 | P00918 | 10/20 | 0.49 |
| ▸ | CA12 | O43570 | 6/20 | 0.49 |
| ▸ | CA9 | Q16790 | 6/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.46 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.46 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939488 | 0.95 | TDP1 (0.57) | TDP1MEN1KMT2AGAACA1 | |
| SCHEMBL423505 | 0.94 | TDP1 (0.59) | TDP1MEN1KMT2AGAACA1 | |
| SCHEMBL21423964 | 0.94 | TDP1 (0.59) | TDP1MEN1KMT2AGAACA1 | |
| SCHEMBL3198212 | 0.90 | TDP1 (0.49) | TDP1MEN1KMT2AGAACA1 | |
| SCHEMBL13288254 | 0.88 | TDP1 (0.59) | TDP1MEN1KMT2AGAACA1 | |
| SCHEMBL572949 | 0.85 | TDP1 (0.56) | TDP1MEN1KMT2AGAACA1 | |
| SCHEMBL6938771 | 0.85 | TDP1 (0.59) | TDP1MEN1KMT2AGAACA1 | |
| SCHEMBL27437838 | 0.84 | TDP1 (0.62) | TDP1MEN1KMT2AGAACA1 | |
| SCHEMBL23477276 | 0.83 | TDP1 (0.61) | TDP1MEN1KMT2AGAACA1 | |
| SCHEMBL20351213 | 0.83 | EPHX1 (0.48) | EPHX1HTTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210015933-A1 | BIOACTIVE CARBOXYLIC ACID TYPE COMPOUND-POLYMER CONJUGATE, AND METHOD FOR MANUFACTURING THE SAME | SEIKAGAKU CORPORATION (JP) | 2021-01-21 | — | — | US | disclosed |
| WO-2018121678-A1 | PRODRUG OF ANTIVIRAL NUCLEOSIDE ANALOGUES, AND COMPOSITION AND USE THEREOF | 广东东阳光药业有限公司 | 2018-07-05 | — | — | WO | disclosed |
| US-8722923-B2 | Conjugates for treating neurodegenerative diseases and disorders | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2014-05-13 | — | — | US | disclosed |
| US-20130059910-A1 | CONJUGATES COMPRISING A GABA- OR GLYCINE COMPOUND, PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS THEREOF AS WELL AS THEIR USE IN TREATING CNS DISORDERS | BAR-ILAN UNIVERSITY (IL) | 2013-03-07 | — | — | US | disclosed |
| US-20130059910-A1 | CONJUGATES COMPRISING A GABA- OR GLYCINE COMPOUND, PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS THEREOF AS WELL AS THEIR USE IN TREATING CNS DISORDERS | BAR-ILAN UNIVERSITY (IL) | 2013-03-07 | — | — | US | disclosed |
| US-20130059910-A1 | CONJUGATES COMPRISING A GABA- OR GLYCINE COMPOUND, PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS THEREOF AS WELL AS THEIR USE IN TREATING CNS DISORDERS | BAR-ILAN UNIVERSITY (IL) | 2013-03-07 | — | — | US | disclosed |
| US-8377990-B2 | Conjugates comprising a psychotropic drug or a GABA agonist and an organic acid and their use in treating pain and other CNS disorders | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2013-02-19 | — | — | US | disclosed |
| US-8377990-B2 | Conjugates comprising a psychotropic drug or a GABA agonist and an organic acid and their use in treating pain and other CNS disorders | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2013-02-19 | — | — | US | disclosed |
| US-8377990-B2 | Conjugates comprising a psychotropic drug or a GABA agonist and an organic acid and their use in treating pain and other CNS disorders | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2013-02-19 | — | — | US | disclosed |
| US-20120277310-A1 | NOVEL CONJUGATES FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS | BAR-ILAN UNIVERSITY (IL) | 2012-11-01 | — | — | US | disclosed |
| EP-2051735-B1 | CONJUGATES COMPRISING A PSYCHOTROPIC DRUG OR A GABA AGONIST AND AN ORGANIC ACID AND THEIR USE TREATING PAIN AND OTHER CNS DISORDERS | UNIV RAMOT (IL) | 2012-08-29 | — | — | EP | disclosed |
| US-8207369-B2 | Conjugates for treating neurodegenerative diseases and disorders | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-06-26 | — | — | US | disclosed |
| US-20110034553-A1 | NOVEL CONJUGATES FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2011-02-10 | — | — | US | disclosed |
| US-20100144869-A1 | Conjugates Comprising a gaba-or glycine compound, pharmaceutical compositions and combinations thereof as well as their use in treating cns disorders | BAR-ILAN UNIVERSITY (IL) | 2010-06-10 | — | — | US | disclosed |
| US-20100144869-A1 | Conjugates Comprising a gaba-or glycine compound, pharmaceutical compositions and combinations thereof as well as their use in treating cns disorders | BAR-ILAN UNIVERSITY (IL) | 2010-06-10 | — | — | US | disclosed |
| US-20100144869-A1 | Conjugates Comprising a gaba-or glycine compound, pharmaceutical compositions and combinations thereof as well as their use in treating cns disorders | BAR-ILAN UNIVERSITY (IL) | 2010-06-10 | — | — | US | disclosed |
| US-7521439-B2 | Glucocorticoid receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2009-04-21 | — | — | US | disclosed |
| US-7521439-B2 | Glucocorticoid receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2009-04-21 | — | — | US | disclosed |
| US-20070027117-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | BISHOP RICHARD D | 2007-02-01 | — | — | US | disclosed |
| US-20070027117-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | BISHOP RICHARD D | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210015933-A1 | BIOACTIVE CARBOXYLIC ACID TYPE COMPOUND-POLYMER CONJUGATE, AND METHOD FOR MANUFACTURING THE SAME | HCAR1, HCAR2, MCCC2 | TDP1 4178/4885MEN1 2134/4885KMT2A 2971/4885 |
| US-20130059910-A1 | CONJUGATES COMPRISING A GABA- OR GLYCINE COMPOUND, PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS THEREOF AS WELL AS THEIR USE IN TREATING CNS DISORDERS | GABBR1, GABRG3, GABBR2 | TDP1 1506/4885MEN1 4204/4885KMT2A 1730/4885 |
| US-20120277310-A1 | NOVEL CONJUGATES FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS | SLC18A2, GABRB2, SLC6A13 | TDP1 328/4885MEN1 4317/4885KMT2A 1823/4885 |
| US-20110034553-A1 | NOVEL CONJUGATES FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS | SLC18A2, SNCA, SLC6A13 | TDP1 262/4885MEN1 4050/4885KMT2A 1498/4885 |
| US-20070027117-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | GPR119, NR3C1, INSR | TDP1 4647/4885MEN1 2794/4885KMT2A 3848/4885 |
| US-20100144869-A1 | Conjugates Comprising a gaba-or glycine compound, pharmaceutical compositions and combinations thereof as well as their use in treating cns disorders | GABBR1, GABRG3, GABBR2 | TDP1 1506/4885MEN1 4204/4885KMT2A 1730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.