SCHEMBL2881680

SCHEMBL2881680

CCCCn1c(=O)c(NC(=O)Nc2c(C(C)C)cc(N)cc2C(C)C)c(-c2cccc(OCCCO)c2)c2cccnc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACAT1 P24752 1/20 1.00
SOAT1 P35610 1/20 0.97

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5953470 0.99 SOAT1 (0.99) ACAT1SOAT1
Hydrochloric Acid SCHEMBL5953844 0.99 SOAT1 (1.00) ACAT1SOAT1
SCHEMBL6635258 0.94 ACAT1 (0.89) ACAT1SOAT1
SCHEMBL31061433 0.94 ACAT1 (0.88) ACAT1SOAT1
SCHEMBL7615047 0.92 ACAT1 (0.85) ACAT1SOAT1
SCHEMBL6639853 0.92 ACAT1 (0.85) ACAT1SOAT1
SCHEMBL7615339 0.90 ACAT1 (0.81) ACAT1SOAT1
SCHEMBL8327206 0.90 ACAT1 (0.81) ACAT1SOAT1
SCHEMBL6632704 0.89 ACAT1 (0.80) ACAT1SOAT1
SCHEMBL8324521 0.89 ACAT1 (0.80) ACAT1SOAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 344 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090192220-A1 TREATMENT FOR SOLID TUMORS ORE PHARMACEUTICALS INC. (US) 2009-07-30 US claimed
US-20070099891-A1 Medicinal compositions and combinations DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2007-05-03 US claimed
EP-1695706-A1 MEDICINAL COMPOSITIONS AND COMBINATIONS Dainippon Sumitomo Pharma Co., Ltd. (JP) 2006-08-30 EP claimed
US-6420381-B1 ACYL-COA: CHOLESTEROL ACYL TRANSFERASE (ACAT) INHIBITORY ACTIVITY, AND IS USEFUL AS AN AGENT FOR TREATMENT OF HYPERLIPIDEMIA AND ATHEROSCLEROSIS. SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2002-07-16 US claimed
CN-116710439-B Substituted pyrazolopiperidine carboxylic acids BAYER AG (DE) 2026-05-26 CN disclosed
EP-4744669-A2 APOLIPOPROTEIN C3 (APOC3) IRNA COMPOSITIONS AND METHODS OF USE THEREOF Alnylam Pharmaceuticals, Inc. (US) 2026-05-20 EP disclosed
CN-116829545-B Substituted pyrazolylpiperidine carboxylic acids 拜耳公司 2026-05-15 CN disclosed
US-12595247-B2 Substituted pyrazolo piperidine carboxylic acids BAYER AKTIENGESELLSCHAFT (DE) 2026-04-07 US disclosed
US-12540134-B2 Inhibitors of adrenoreceptor ADRAC2 BAYER AKTIENGESELLSCHAFT (DE) 2026-02-03 US disclosed
US-12522822-B2 Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof ALNYLAM PHARMACEUTICALS, INC. (US) 2026-01-13 US disclosed
US-12503469-B2 Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3-4-b]pyridino-3-yl]pyrimidino-5-yl} methyl carbamate ADVERIO PHARMA GMBH (DE) 2025-12-23 US disclosed
US-20250361282-A1 ATRIAL NATRIURETIC PEPTIDE ENGRAFTED ANTIBODIES BAYER AKTIENGESELLSCHAFT (DE) 2025-11-27 US disclosed
WO-2008017381-A1 ARYLAMINOARYL-ALKYL-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, PROCESSES FOR PREPARING THEM, MEDICAMENTS COMPRISING THESE COMPOUNDS, AND THEIR USE SANOFI-AVENTIS (FR) 2008-02-14 WO disclosed
US-20070099891-A1 Medicinal compositions and combinations DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2007-05-03 US disclosed
EP-1695706-A1 MEDICINAL COMPOSITIONS AND COMBINATIONS Dainippon Sumitomo Pharma Co., Ltd. (JP) 2006-08-30 EP disclosed
JP-2006063066-A MEDICINAL COMPOSITION HAVING ANTI-ARTERIOSCLEROTIC ACTION SANKYO CO LTD 2006-03-09 JP disclosed
WO-2006011551-A1 PHARMACEUTICAL COMPOSITION HAVING ANTI-ARTERIOSCLEROSIS POTENCY SANKYO COMPANY LIMITED (JP) 2006-02-02 WO disclosed
EP-1420017-A1 1,2-DIHYDRO-2-OXO-1,8-NAPHTHYRIDINE DERIVATIVE SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2004-05-19 EP disclosed
US-6420381-B1 ACYL-COA: CHOLESTEROL ACYL TRANSFERASE (ACAT) INHIBITORY ACTIVITY, AND IS USEFUL AS AN AGENT FOR TREATMENT OF HYPERLIPIDEMIA AND ATHEROSCLEROSIS. SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2002-07-16 US disclosed
EP-1104763-A1 NAPHTHYRIDINE DERIVATIVES SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2001-06-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12503469-B2 Forms of methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3-4-b]pyridino-3-yl]pyrimidino-5-yl} methyl carbamate KDM2B, KDM6B, KDM3B ACAT1 3260/4885SOAT1 4466/4885
US-12540134-B2 Inhibitors of adrenoreceptor ADRAC2 ADRA2C, ADRB3, ADRB2 ACAT1 997/4885SOAT1 1453/4885
US-20090192220-A1 TREATMENT FOR SOLID TUMORS ACAT2, ACAT1, APRT ACAT1 2/4885SOAT1 65/4885
US-12595247-B2 Substituted pyrazolo piperidine carboxylic acids SSB, PDK4, FPR1 ACAT1 2964/4885SOAT1 3211/4885
US-20070099891-A1 Medicinal compositions and combinations HMGCR, APOB, CYP46A1 ACAT1 69/4885SOAT1 46/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.