Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28111242 | 0.90 | RAB9A (0.53) | SMN1; SMN2MMP13CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL28111738 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2MMP13CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL27021656 | 0.73 | KMT2A (0.65) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL28111733 | 0.73 | MMP13 (0.52) | SMN1; SMN2MMP13CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5370386 | 0.69 | MMP13 (0.62) | SMN1; SMN2MMP13CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL17661849 | 0.69 | HPGD (0.60) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL21644655 | 0.67 | HSP90AA1 (0.64) | SMN1; SMN2CYP2C19ALDH1A1KMT2AHPGD | |
| SCHEMBL2373449 | 0.66 | AMY1A (0.57) | SMN1; SMN2MMP13ALDH1A1MEN1KMT2A | |
| SCHEMBL28836629 | 0.66 | VNN1 (0.56) | SMN1; SMN2MMP13MEN1KMT2AMAPT | |
| SCHEMBL28111776 | 0.66 | MAPT (0.64) | MMP13CYP1A2CYP2C19ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106187910-A | Pyridazine class derivant and its production and use | 浙江大学 | 2016-12-07 | — | — | CN | claimed |
| CN-106187910-A | Pyridazine class derivant and its production and use | 浙江大学 | 2016-12-07 | — | — | CN | disclosed |