Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.41 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL336794 | 0.93 | ZDHHC20 (0.46) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| SCHEMBL4126549 | 0.92 | ZDHHC20 (0.47) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Bromide SCHEMBL25324391 | 0.90 | ZDHHC20 (0.46) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Chloromethane SCHEMBL28028247 | 0.88 | ZDHHC20 (0.44) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Acrylic Acid SCHEMBL396773 | 0.87 | ZDHHC20 (0.41) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Acrylamide SCHEMBL28599343 | 0.86 | ZDHHC20 (0.35) | ZDHHC20ZDHHC2 | |
| Acrylic Acid SCHEMBL28592507 | 0.83 | ZDHHC20 (0.33) | ZDHHC20ZDHHC2 | |
| Hydrochloric Acid SCHEMBL27944735 | 0.81 | TSHR (0.42) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| SCHEMBL29142619 | 0.81 | ZDHHC20 (0.53) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL28470855 | 0.81 | ZDHHC20 (0.57) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109425686-B | Method for detecting cationic degree of synthetic polymer for drilling fluid | 中石化石油工程技术服务有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-109589279-A | A kind of solid shampoo and preparation method thereof | 明辉实业（深圳）有限公司 | 2019-04-09 | — | — | CN | disclosed |