Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Acrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.41 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL336794 | 0.93 | ZDHHC20 (0.46) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| SCHEMBL4126549 | 0.92 | ZDHHC20 (0.47) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Bromide SCHEMBL25324391 | 0.90 | ZDHHC20 (0.46) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Chloromethane SCHEMBL28028247 | 0.88 | ZDHHC20 (0.44) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Acrylamide SCHEMBL28870529 | 0.87 | ZDHHC20 (0.41) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| SCHEMBL28180741 | 0.82 | ZDHHC20 (0.37) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| SCHEMBL29142619 | 0.81 | ZDHHC20 (0.53) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL28470855 | 0.81 | ZDHHC20 (0.57) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL4534755 | 0.79 | TSHR (0.46) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL27944735 | 0.78 | TSHR (0.42) | ZDHHC20ZDHHC2ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101574-B2 | Oligopeptides and compositions containing the oligopeptides | COGNIS IP MANAGEMENT GMBH (DE) | 2012-01-24 | — | — | US | disclosed |
| US-7871766-B2 | Cosmetic and/or dermopharmaceutical preparations containing native proteins from the plant Argania spinosa | COGNIS IP MANAGEMENT GMBH (DE) | 2011-01-18 | — | — | US | disclosed |
| US-20100260697-A1 | Composition Containing An Extract of the Fruit of Schisandra Chinensis and Process for Producing Same | COGNIS FRANCE S.A.S. (FR) | 2010-10-14 | — | — | US | disclosed |
| US-7722901-B2 | Uses for the extract of a plant of the family Asclepiadaceae | COGNIS IP MANAGEMENT GMBH (DE) | 2010-05-25 | — | — | US | disclosed |
| US-20090075906-A1 | OLIGOPEPTIDES AND COMPOSITIONS CONTAINING THE OLIGOPEPTIDES | COGNIS IP MANAGEMENT GMBH (DE) | 2009-03-19 | — | — | US | disclosed |
| US-20070128302-A1 | Composition containing an extract of the fruit of schisandra chinensis and process for producing same | COGNIS FRANCE S.A. (FR) | 2007-06-07 | — | — | US | disclosed |
| US-20040042996-A1 | Cosmetic and/or dermopharmaceutical preparations containing native proteins from the plant argania spinosa | COGNIS FRANCE S.A.S. (FR) | 2004-03-04 | — | — | US | disclosed |
| US-20030170298-A1 | Proliposomal encapsulated preparations | COGNIS IBERIA S.L. (ES) | 2003-09-11 | — | — | US | disclosed |
| US-20030138394-A1 | Cosmetic and/or pharmaceutical preparations that contain an extract of the plant argania spinosa | COGNIS FRANCE S.A. (FR) | 2003-07-24 | — | — | US | disclosed |
| US-20030068364-A1 | Pro-liposomal encapsulated preparations (iv) | COGNIS IBERIA S.L (ES) | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075906-A1 | OLIGOPEPTIDES AND COMPOSITIONS CONTAINING THE OLIGOPEPTIDES | SGMS2, HRH3, CERT1 | ZDHHC20 46/4885ZDHHC2 89/4885ALDH1A1 4694/4885 |
| US-20030138394-A1 | Cosmetic and/or pharmaceutical preparations that contain an extract of the plant argania spinosa | ARG1, ARG2, CUTA | ZDHHC20 1282/4885ZDHHC2 2518/4885ALDH1A1 3916/4885 |
| US-20030068364-A1 | Pro-liposomal encapsulated preparations (iv) | PHOSPHO1, LIPA, PLIN5 | ZDHHC20 1201/4885ZDHHC2 2051/4885ALDH1A1 3463/4885 |
| US-20030170298-A1 | Proliposomal encapsulated preparations | LIPA, PLIN5, PNLIP | ZDHHC20 394/4885ZDHHC2 754/4885ALDH1A1 1832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.