Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28928826 | 0.84 | PKM (0.40) | LMNAMTNR1AMTNR1B | |
| SCHEMBL28928862 | 0.83 | KDM4E (0.41) | NPC1LMNAGAAKDM4ERAB9A | |
| SCHEMBL28929181 | 0.82 | AOC3 (0.43) | NPC1GAAKDM4ERAB9A | |
| SCHEMBL28928858 | 0.79 | NPC1 (0.44) | NPC1MAPTMAPK1HSD17B10LMNA | |
| SCHEMBL28928831 | 0.76 | KDM4E (0.42) | LMNAGAAKDM4EPOLB | |
| SCHEMBL28929413 | 0.76 | GAA (0.45) | LMNAGAAKDM4E | |
| SCHEMBL28928818 | 0.73 | NPC1 (0.51) | NPC1MAPTLMNAGAAKDM4E | |
| SCHEMBL28928832 | 0.71 | NPC1 (0.45) | NPC1MAPTHSD17B10LMNAGAA | |
| SCHEMBL28928852 | 0.71 | GAA (0.42) | NPC1LMNAGAAKDM4ERAB9A | |
| SCHEMBL28928872 | 0.69 | LMNA (0.62) | NPC1LMNAKDM4ERAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115583942-A | 2-substituted 5-phenyl-oxazole derivative, preparation method thereof and application thereof as MNK (MNK) inhibitor | 中国海洋大学 | 2023-01-10 | — | — | CN | disclosed |