Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460381 | 0.82 | HCRTR1 (0.41) | L3MBTL1ALDH1A1 | |
| SCHEMBL290017 | 0.81 | KMT2A (0.43) | FAAHFEN1L3MBTL1ALDH1A1PTGER4 | |
| SCHEMBL288186 | 0.79 | SMN1; SMN2 (0.46) | FAAHFEN1LMNAALDH1A1PTGER4 | |
| SCHEMBL288654 | 0.70 | GYS1 (0.50) | FAAHFEN1CCR2SIRT2SIRT1 | |
| SCHEMBL1613572 | 0.70 | GYS1 (0.50) | FAAHFEN1CCR2SIRT2SIRT1 | |
| SCHEMBL7364966 | 0.70 | L3MBTL1 (0.47) | FAAHCCR2L3MBTL1PARGCYP19A1 | |
| SCHEMBL7424115 | 0.68 | L3MBTL1 (0.54) | FAAHSIRT2SIRT1L3MBTL1CYP19A1 | |
| SCHEMBL29809178 | 0.68 | L3MBTL1 (0.54) | FAAHSIRT2SIRT1L3MBTL1CYP19A1 | |
| SCHEMBL8443442 | 0.68 | CCR2 (0.56) | FAAHFEN1CCR2LMNAFFAR1 | |
| SCHEMBL3903191 | 0.68 | FAAH (0.53) | FAAHFEN1CCR2SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427429-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128102-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2010-11-11 | — | — | WO | disclosed |