Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pyrogallol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 2/20 | 0.42 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.67 |
| ▸ | CDK2 | P24941 | 3/20 | 0.67 |
| ▸ | CA2 | P00918 | 3/20 | 0.67 |
| ▸ | EGFR | P00533 | 2/20 | 0.67 |
| ▸ | CA1 | P00915 | 2/20 | 0.67 |
| ▸ | FYN | P06241 | 2/20 | 0.67 |
| ▸ | MMP9 | P14780 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.67 |
| ▸ | MMP2 | P08253 | 1/20 | 0.67 |
| ▸ | MMP8 | P22894 | 1/20 | 0.67 |
| ▸ | CA6 | P23280 | 1/20 | 0.67 |
| ▸ | MMP12 | P39900 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrogallol SCHEMBL17768460 | 0.97 | ALDH1A1 (0.71) | ALDH1A1ALOX15HSD17B10LMNAHPGD | |
| Pyrogallol SCHEMBL214769 | 0.86 | ALDH1A1 (0.63) | ALDH1A1ALOX15HSD17B10LMNAHPGD | |
| Pyrogallol SCHEMBL209233 | 0.86 | ALDH1A1 (0.63) | ALDH1A1ALOX15HSD17B10LMNAHPGD | |
| Pyrogallol SCHEMBL28234833 | 0.86 | CA2 (0.71) | ALDH1A1ALOX15HSD17B10LMNAHPGD | |
| Pyrogallol SCHEMBL11324823 | 0.85 | ALDH1A1 (0.92) | ALDH1A1ALOX15HSD17B10LMNAHPGD | |
| Pyrogallol SCHEMBL704091 | 0.82 | ALDH1A1 (0.57) | ALDH1A1ALOX15HSD17B10LMNAHPGD | |
| Pyrogallol SCHEMBL1056082 | 0.82 | ALDH1A1 (0.57) | ALDH1A1ALOX15HSD17B10LMNAHPGD | |
| Pyrogallol SCHEMBL2900972 | 0.82 | ALDH1A1 (0.57) | ALDH1A1ALOX15HSD17B10LMNAHPGD | |
| Pyrogallol SCHEMBL16714223 | 0.82 | ALDH1A1 (0.57) | ALDH1A1ALOX15HSD17B10LMNAHPGD | |
| Pyrogallol SCHEMBL28169630 | 0.82 | ALDH1A1 (0.86) | ALDH1A1ALOX15HSD17B10LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112457172-B | Preparation method of high-safety hydroquinone composition | 广东人人康药业有限公司（CN） | 2023-01-13 | — | — | CN | claimed |
| CN-112353760-B | Water-in-oil type compound hydroquinone emulsion as well as preparation method and application thereof | 广东人人康药业有限公司（CN） | 2023-01-13 | — | — | CN | claimed |