Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 2/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL278264 | 0.85 | ALDH1A1 (0.60) | ALDH1A1MMP3BCL2L1CA1CA2 | |
| Biphenyl SCHEMBL28994599 | 0.82 | ALDH1A1 (0.56) | ALDH1A1MMP3BCL2L1CA1CA2 | |
| Biphenyl SCHEMBL15610250 | 0.78 | ALDH1A1 (0.69) | ALDH1A1MMP3BCL2L1CA1CA2 | |
| Potassium Ion SCHEMBL11325717 | 0.77 | ALDH1A1 (0.43) | ALDH1A1MMP3BCL2L1PTPN1PTPN11 | |
| Phenol SCHEMBL11154792 | 0.76 | CA2 (0.58) | ALDH1A1MMP3BCL2L1CA1CA2 | |
| Biphenyl SCHEMBL27650730 | 0.75 | ALDH1A1 (0.75) | ALDH1A1MMP3BCL2L1CA1CA2 | |
| Biphenyl SCHEMBL28098924 | 0.74 | ALDH1A1 (0.90) | ALDH1A1MMP3BCL2L1CRHBPCRHR2 | |
| Sulfurous Acid SCHEMBL1825613 | 0.74 | EPHX1 (0.33) | ALDH1A1CA2MAPTSMN1; SMN2LMNA | |
| SCHEMBL10011964 | 0.74 | MMP3 (0.46) | ALDH1A1MMP3BCL2L1PTPN1CA1 | |
| SCHEMBL7530139 | 0.74 | MMP3 (0.46) | ALDH1A1MMP3BCL2L1PTPN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116963738-A | Luminol for the prevention and treatment of sequelae of SARS-CoV-2 infection | 麦翠奥制药公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116075306-A | Compounds for the treatment of coronavirus infections | 麦翠奥制药公司 | 2023-05-05 | — | — | CN | disclosed |