Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | F2R | P25116 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2903222 | 0.85 | ALDH1A1 (0.54) | MAPTLMNACCR2NPC1RAB9A | |
| SCHEMBL2903225 | 0.85 | ALDH1A1 (0.54) | MAPTLMNACCR2NPC1RAB9A | |
| SCHEMBL4508730 | 0.82 | MAPT (0.67) | MAPTL3MBTL1F2RLMNACCR2 | |
| SCHEMBL2903643 | 0.81 | CCR2 (0.61) | CCR2 | |
| SCHEMBL2903645 | 0.81 | CCR2 (0.61) | CCR2 | |
| SCHEMBL2903457 | 0.81 | CCR2 (0.51) | LMNACCR2MEN1ALDH1A1KMT2A | |
| SCHEMBL2903456 | 0.81 | CCR2 (0.51) | LMNACCR2MEN1ALDH1A1KMT2A | |
| SCHEMBL2903223 | 0.76 | SIGMAR1 (0.47) | LMNAHPGDSIGMAR1ALDH1A1KMT2A | |
| SCHEMBL2903699 | 0.76 | RAB9A (0.58) | MAPTL3MBTL1F2RLMNANPC1 | |
| SCHEMBL2903702 | 0.76 | RAB9A (0.58) | MAPTL3MBTL1F2RLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |