Sugi Predict

Sugi Predict / Compounds / SCHEMBL2912487

SCHEMBL2912487

SCHEMBL2912487

COC(=O)Cc1cc(Br)ccc1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.41
▸ SMN1; SMN2 Q16637 2/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ PDGFRB P09619 1/20 0.41
▸ FGFR1 P11362 1/20 0.41
▸ PDGFRA P16234 1/20 0.41
▸ FLT1 P17948 1/20 0.41
▸ FGFR3 P22607 1/20 0.41
▸ KDR P35968 1/20 0.41
▸ HSP90AB1 P08238 1/20 0.41
▸ KDM4E B2RXH2 4/20 0.40
▸ MEN1 O00255 3/20 0.40
▸ ALDH1A1 P00352 3/20 0.40
▸ KMT2A Q03164 3/20 0.40
▸ GLA P06280 2/20 0.40
▸ GAA P10253 2/20 0.39
▸ LMNA P02545 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ FFAR4 Q5NUL3 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13751380 0.86 HPGD (0.45) HPGDSMN1; SMN2NPC1RAB9APDGFRB
SCHEMBL5954084 0.84 HPGD (0.42) HPGDSMN1; SMN2HSP90AB1KDM4EMEN1
SCHEMBL14446956 0.84 HPGD (0.42) HPGDSMN1; SMN2HSP90AB1KDM4EMEN1
SCHEMBL5582368 0.83 HPGD (0.50) HPGDSMN1; SMN2KDM4EMEN1ALDH1A1
SCHEMBL2400437 0.83 EGFR (0.55) HPGDHSP90AB1KDM4EALDH1A1KMT2A
SCHEMBL20561914 0.83 HPGD (0.41) HPGDSMN1; SMN2HSP90AB1KDM4EMEN1
SCHEMBL16410591 0.82 PTGER1 (0.47) SMN1; SMN2NPC1RAB9AKDM4EMEN1
SCHEMBL12650135 0.82 NPC1 (0.45) HPGDSMN1; SMN2NPC1RAB9APDGFRB
SCHEMBL24097691 0.81 HPGD (0.41) HPGDSMN1; SMN2HSP90AB1KDM4EMEN1
SCHEMBL137400 0.81 KDM4E (0.56) HPGDSMN1; SMN2KDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12617777-B2 GPR84 antagonists and uses thereof Liminal Biosciences Limited (GB) 2026-05-05 — — US disclosed
EP-4288427-A1 GPR84 ANTAGONISTS AND USES THEREOF Liminal Biosciences Limited (GB) 2023-12-13 — — EP disclosed
CN-117098757-A GPR84 antagonists and uses thereof 里米诺生物科学有限公司 2023-11-21 — — CN disclosed
US-20230354808-A1 METHOD OF CONTROLLING SOYBEAN RUST FUNGUS RESISTANT TO QOI FUNGICIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-11-09 — — US disclosed
US-20230150909-A1 PHENYLACETIC ACID DERIVATIVE, USE THEREFOR, AND PRODUCTION INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-05-18 — — US disclosed
US-20230113202-A1 GPR84 ANTAGONISTS AND USES THEREOF Liminal Biosciences Limited (GB) 2023-04-13 — — US disclosed
WO-2022167457-A1 GPR84 ANTAGONISTS AND USES THEREOF Liminal Biosciences Limited (GB) 2022-08-11 — — WO disclosed
WO-2021153786-A1 PHENYLACETIC ACID DERIVATIVE, USE THEREFOR, AND PRODUCTION INTERMEDIATE THEREOF 住友化学株式会社 2021-08-05 — — WO disclosed
WO-2021153794-A1 METHOD OF CONTROLLING SOYBEAN RUST FUNGUS RESISTANT TO QOI FUNGICIDE 住友化学株式会社 2021-08-05 — — WO disclosed
US-20200131144-A1 AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS PHENEX-FXR GMBH (DE) 2020-04-30 — — US disclosed
EP-1979355-B1 SPIRO IMIDAZOLE DERIVATIVES AS PPAR MODULATORS IRM LLC (BM) 2010-08-18 — — EP disclosed
US-20090137610-A1 SPIRO IMIDOZOLE DERIVATIVES AS PPAR MODULATORS IRM LLC (BM) 2009-05-28 — — US disclosed
US-20090137610-A1 SPIRO IMIDOZOLE DERIVATIVES AS PPAR MODULATORS IRM LLC (BM) 2009-05-28 — — US disclosed
US-20090137610-A1 SPIRO IMIDOZOLE DERIVATIVES AS PPAR MODULATORS IRM LLC (BM) 2009-05-28 — — US disclosed
US-20080275114-A1 Inhibitors of Ccr9 Activity NOVARTIS AG (CH) 2008-11-06 — — US disclosed
EP-1979355-A1 SPIRO IMIDAZOLE DERIVATIVES AS PPAR MODULATORS IRM LLC (BM) 2008-10-15 — — EP disclosed
US-20080188371-A1 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-08-07 — — US disclosed
WO-2007087448-A1 SPIRO IMIDAZOLE DERIVATIVES AS PPAR MODULATORS IRM LLC (BM) 2007-08-02 — — WO disclosed
WO-2007087448-A1 SPIRO IMIDAZOLE DERIVATIVES AS PPAR MODULATORS IRM LLC (BM) 2007-08-02 — — WO disclosed
WO-2007071443-A1 INHIBITORS OF CCR9 ACTIVITY NOVARTIS AG (CH) 2007-06-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230113202-A1 GPR84 ANTAGONISTS AND USES THEREOF GPR84, GPR88, GPR65 HPGD 1683/4885SMN1; SMN2 3154/4885NPC1 315/4885
US-20230354808-A1 METHOD OF CONTROLLING SOYBEAN RUST FUNGUS RESISTANT TO QOI FUNGICIDE SQOR, CYC1, COX5B HPGD 2679/4885SMN1; SMN2 3939/4885NPC1 2400/4885
US-20080275114-A1 Inhibitors of Ccr9 Activity CCR9, CCR1, CCR4 HPGD 2174/4885SMN1; SMN2 2056/4885NPC1 342/4885
US-12617777-B2 GPR84 antagonists and uses thereof GPR84, GPR88, GPR3 HPGD 2244/4885SMN1; SMN2 1897/4885NPC1 433/4885
US-20080188371-A1 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives DDT, CYP4X1, HPD HPGD 1646/4885SMN1; SMN2 4748/4885NPC1 4762/4885
US-20090137610-A1 SPIRO IMIDOZOLE DERIVATIVES AS PPAR MODULATORS PPARD, PPARG, PPARA HPGD 302/4885SMN1; SMN2 3127/4885NPC1 831/4885
US-20200131144-A1 AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS NR1H2, NR1H3, NR1H4 HPGD 1518/4885SMN1; SMN2 4873/4885NPC1 79/4885
US-20230150909-A1 PHENYLACETIC ACID DERIVATIVE, USE THEREFOR, AND PRODUCTION INTERMEDIATE THEREOF FAR1, NOTUM, ME1 HPGD 1711/4885SMN1; SMN2 4429/4885NPC1 2298/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.