Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 2/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL29366645 | 0.92 | KMT2A (0.56) | KMT2AMEN1LMNASLC34A1FDPS | |
| Tromethamine SCHEMBL2202687 | 0.83 | KMT2A (0.59) | KMT2AMEN1LMNASLC34A1FDPS | |
| Tromethamine SCHEMBL7899122 | 0.83 | LMNA (0.67) | KMT2AMEN1LMNAFDPSGRM4 | |
| Tromethamine SCHEMBL1509014 | 0.83 | LMNA (0.67) | KMT2AMEN1LMNAFDPSGRM4 | |
| Tromethamine SCHEMBL2188 | 0.76 | — | — | |
| Tromethamine SCHEMBL1524832 | 0.76 | MEN1 (0.91) | KMT2AMEN1LMNAKDM4ES1PR1 | |
| Tromethamine SCHEMBL445853 | 0.76 | MEN1 (0.91) | KMT2AMEN1LMNAKDM4ES1PR1 | |
| Tromethamine SCHEMBL2313359 | 0.76 | MEN1 (0.91) | KMT2AMEN1LMNAKDM4ES1PR1 | |
| Tromethamine SCHEMBL1270294 | 0.76 | MEN1 (0.91) | KMT2AMEN1LMNAKDM4ES1PR1 | |
| Tromethamine SCHEMBL9580813 | 0.76 | MEN1 (0.91) | KMT2AMEN1LMNAKDM4ES1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114940756-B | Poly (2-oxazoline) lipid and lipid nanoparticle and application | 北京清科胜因生物科技有限公司 | 2023-11-07 | — | — | CN | disclosed |