Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | FDPS | P14324 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA4 | P22748 | 2/20 | 0.32 |
| ▸ | CA5A | P35218 | 2/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL29366645 | 0.92 | KMT2A (0.56) | KMT2ALMNAMEN1FDPSKDM4E | |
| Tromethamine SCHEMBL29130482 | 0.83 | KMT2A (0.53) | KMT2ALMNAMEN1FDPSKDM4E | |
| Tromethamine SCHEMBL1509014 | 0.81 | LMNA (0.67) | KMT2ALMNAMEN1FDPSKDM4E | |
| Tromethamine SCHEMBL7899122 | 0.81 | LMNA (0.67) | KMT2ALMNAMEN1FDPSKDM4E | |
| Tromethamine SCHEMBL1285696 | 0.77 | MEN1 (0.83) | KMT2ALMNAMEN1KDM4E | |
| Tromethamine SCHEMBL20658226 | 0.77 | MEN1 (0.83) | KMT2ALMNAMEN1KDM4E | |
| Tromethamine SCHEMBL975 | 0.77 | — | — | |
| Tromethamine SCHEMBL17484 | 0.77 | MEN1 (1.00) | KMT2ALMNAMEN1KDM4ES1PR1 | |
| Phosphoric Acid SCHEMBL27256579 | 0.75 | KDM4E (0.36) | KMT2ALMNAFDPSKDM4ECYP2C19 | |
| Tromethamine SCHEMBL7572662 | 0.74 | LMNA (0.56) | KMT2ALMNAMEN1FDPSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748083-A1 | Methods and reagents for detecting target nucleic acids | Roche Diagnostics GmbH (DE) | 2007-01-31 | — | — | EP | claimed |
| US-7977108-B2 | Method for detecting a mutation in a repetitive nucleic acid sequence | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20070031870-A1 | Methods and reagents for detecting target nucleic acids | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2007-02-08 | — | — | US | disclosed |
| EP-1748083-A1 | Methods and reagents for detecting target nucleic acids | Roche Diagnostics GmbH (DE) | 2007-01-31 | — | — | EP | disclosed |
| US-20050227225-A1 | Stabilization of biomolecules in samples | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2005-10-13 | — | — | US | disclosed |
| EP-1584923-A2 | Stabilization of biomolecules in samples | Roche Diagnostics GmbH (DE) | 2005-10-12 | — | — | EP | disclosed |