Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.42 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10876734 | 0.89 | PLA2G4B (0.53) | TSHRTP53SMN1; SMN2ALOX15PLA2G2A | |
| SCHEMBL9696756 | 0.83 | TSHR (0.52) | TSHRTP53SMN1; SMN2ALOX15RECQL | |
| SCHEMBL1018288 | 0.82 | CA2 (0.52) | TSHRTP53SMN1; SMN2ALOX15PLA2G2A | |
| SCHEMBL12365457 | 0.80 | ALDH1A1 (0.53) | TSHRTP53SMN1; SMN2ALOX15PLA2G2A | |
| SCHEMBL1017821 | 0.80 | HTT (0.51) | TSHRTP53SMN1; SMN2PLA2G2AHTT | |
| SCHEMBL5848182 | 0.80 | ALDH1A1 (0.48) | TSHRTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1018124 | 0.78 | CA2 (0.54) | TSHRTP53SMN1; SMN2PLA2G2ANPC1 | |
| Hydrochloric Acid SCHEMBL28033163 | 0.78 | TSHR (0.46) | TSHRTP53SMN1; SMN2ALOX15PLA2G2A | |
| SCHEMBL10366613 | 0.78 | ALDH1A1 (0.52) | TSHRSMN1; SMN2NPC1RAB9AALDH1A1 | |
| Terephthalic Acid SCHEMBL9017252 | 0.78 | TSHR (0.71) | TSHRTP53SMN1; SMN2ALOX15RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028942-B1 | DIPEPTIDE NITRILES | NOVARTIS AG (CH) | 2010-09-01 | — | — | EP | disclosed |
| US-20080027060-A1 | DIPEPTIDE NITRILES | ALTMANN EVA | 2008-01-31 | — | — | US | disclosed |
| US-20060235220-A1 | Dipeptide nitriles | MISSBACH MARTIN | 2006-10-19 | — | — | US | disclosed |
| US-20040110806-A1 | Dipeptide derivatives | ALTMANN EVA (CH) | 2004-06-10 | — | — | US | disclosed |
| US-20040029814-A1 | Dipeptide nitriles | ALTMANN EVA (CH) | 2004-02-12 | — | — | US | disclosed |
| US-6353017-B1 | INHIBITORS OF CATHESPINS USING DIPEPTIDE NITRILES AS ANTIINFLAMMATORY AGENTS AND ANTIARTHRITIC AGENTS | NOVARTIS AG (CH) | 2002-03-05 | — | — | US | disclosed |
| EP-1028942-A2 | DIPEPTIDE NITRILES | Novartis AG (CH) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024460-A2 | DIPEPTIDE NITRILES | NOVARTIS AG (CH) | 1999-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110806-A1 | Dipeptide derivatives | CTSL, CTSZ, CTSS | TSHR 2994/4885TP53 155/4885SMN1; SMN2 4548/4885 |
| US-20040029814-A1 | Dipeptide nitriles | NOS1, CTSL, CTSS | TSHR 2883/4885TP53 200/4885SMN1; SMN2 4277/4885 |
| US-20060235220-A1 | Dipeptide nitriles | CTSL, CTSS, CTSB | TSHR 2383/4885TP53 99/4885SMN1; SMN2 4307/4885 |
| US-20080027060-A1 | DIPEPTIDE NITRILES | CTSL, CTSS, CTSB | TSHR 2383/4885TP53 99/4885SMN1; SMN2 4307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.