Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 2/20 | 0.65 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.65 |
| ▸ | PIN1 | Q13526 | 7/20 | 0.62 |
| ▸ | CTSK | P43235 | 4/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916297 | 1.00 | GRN (0.65) | GRNSORT1PIN1CTSKCASP1 | |
| SCHEMBL7427022 | 0.91 | PIN1 (0.56) | GRNSORT1PIN1CTSKCASP1 | |
| SCHEMBL7421313 | 0.89 | PIN1 (0.54) | GRNSORT1PIN1CTSKCASP1 | |
| SCHEMBL4211750 | 0.86 | TAS1R3 (0.71) | TAS1R3TAS1R1 | |
| SCHEMBL11918871 | 0.86 | TAS1R3 (0.71) | TAS1R3TAS1R1 | |
| SCHEMBL4211753 | 0.86 | TAS1R3 (0.71) | TAS1R3TAS1R1 | |
| SCHEMBL12984637 | 0.84 | PIN1 (0.70) | PIN1CA2CA1 | |
| SCHEMBL13753280 | 0.84 | MLYCD (0.55) | PIN1CTSKCASP1CASP3TAS1R3 | |
| SCHEMBL12984634 | 0.84 | PIN1 (0.70) | PIN1CA2CA1 | |
| SCHEMBL2158900 | 0.84 | CTSL (0.67) | GRNSORT1CTSKCA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050118409-A1 | Chelator-modified inorganic oxide particles | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-06-02 | — | — | US | claimed |
| WO-2005037397-A1 | CHELATOR-MODIFIED INORGANIC OXIDE PARTICLES | ZIRCHROM SEPARATIONS, INC. (US) | 2005-04-28 | — | — | WO | claimed |
| EP-1028942-B1 | DIPEPTIDE NITRILES | NOVARTIS AG (CH) | 2010-09-01 | — | — | EP | disclosed |
| US-20080027060-A1 | DIPEPTIDE NITRILES | ALTMANN EVA | 2008-01-31 | — | — | US | disclosed |
| US-20060235220-A1 | Dipeptide nitriles | MISSBACH MARTIN | 2006-10-19 | — | — | US | disclosed |
| CN-1273444-C | Dipeptide nitriles | NOVARTIS AG (CH) | 2006-09-06 | — | — | CN | disclosed |
| US-20040110806-A1 | Dipeptide derivatives | ALTMANN EVA (CH) | 2004-06-10 | — | — | US | disclosed |
| US-20040029814-A1 | Dipeptide nitriles | ALTMANN EVA (CH) | 2004-02-12 | — | — | US | disclosed |
| US-6353017-B1 | INHIBITORS OF CATHESPINS USING DIPEPTIDE NITRILES AS ANTIINFLAMMATORY AGENTS AND ANTIARTHRITIC AGENTS | NOVARTIS AG (CH) | 2002-03-05 | — | — | US | disclosed |
| CN-1278244-A | Dipeptide nitriles | NOVARTIS AG (CH) | 2000-12-27 | — | — | CN | disclosed |
| EP-1028942-A2 | DIPEPTIDE NITRILES | Novartis AG (CH) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024460-A2 | DIPEPTIDE NITRILES | NOVARTIS AG (CH) | 1999-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110806-A1 | Dipeptide derivatives | CTSL, CTSZ, CTSS | GRN 1633/4885SORT1 1978/4885PIN1 2115/4885 |
| US-20040029814-A1 | Dipeptide nitriles | NOS1, CTSL, CTSS | GRN 1468/4885SORT1 2215/4885PIN1 2691/4885 |
| US-20060235220-A1 | Dipeptide nitriles | CTSL, CTSS, CTSB | GRN 1381/4885SORT1 2086/4885PIN1 1458/4885 |
| US-20080027060-A1 | DIPEPTIDE NITRILES | CTSL, CTSS, CTSB | GRN 1381/4885SORT1 2086/4885PIN1 1458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.