Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31677332 | 0.91 | MGLL (0.34) | KMT2APOLBMGLLTSHRHSD11B1 | |
| SCHEMBL30864109 | 0.91 | GPR119 (0.40) | KMT2A | |
| SCHEMBL29201733 | 0.90 | TSHR (0.34) | KMT2AMGLLCHRM4DDR1TSHR | |
| SCHEMBL29201746 | 0.89 | MGLL (0.39) | MGLLTSHRNPSR1HSD11B1 | |
| SCHEMBL29277059 | 0.86 | HSD11B1 (0.39) | MGLLTSHRNPSR1HSD11B1HTR1A | |
| SCHEMBL27143092 | 0.85 | MGLL (0.42) | MGLLTSHRNPSR1HSD11B1 | |
| SCHEMBL27147744 | 0.83 | NAMPT (0.36) | MGLLTSHRHSD11B1HTR1A | |
| SCHEMBL31677350 | 0.83 | TSHR (0.35) | MGLLTSHRNPSR1HSD11B1 | |
| SCHEMBL29201758 | 0.82 | HTT (0.40) | MGLLHTTHSD11B1 | |
| SCHEMBL31697885 | 0.82 | MGLL (0.39) | MGLLTSHRNPSR1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |