Sugi Predict

Sugi Predict / Compounds / SCHEMBL2922016

SCHEMBL2922016

SCHEMBL2922016

CCOC(=O)c1cn2ccncc2n1

nearest known ligand 0.63

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 8/20 0.63
▸ POLB P06746 1/20 0.63
▸ ALDH1A1 P00352 1/20 0.56
▸ HPGD P15428 1/20 0.56
▸ HRH4 Q9H3N8 1/20 0.53
▸ GAA P10253 1/20 0.50
▸ RAB9A P51151 5/20 0.46
▸ MAPT P10636 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ CYP1A2 P05177 1/20 0.44
▸ NPC1 O15118 3/20 0.43
▸ RXFP1 Q9HBX9 1/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ GABRA2 P47869 4/20 0.42
▸ GABRB2 P47870 4/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ MLYCD O95822 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31341116 0.83 HRH4 (0.47) KDM4EPOLBALDH1A1HPGDHRH4
SCHEMBL19997261 0.81 HRH4 (0.57) KDM4EPOLBALDH1A1HPGDHRH4
SCHEMBL15176026 0.79 KDM4E (0.62) KDM4EPOLBALDH1A1HPGDGAA
SCHEMBL101682 0.79 KDM4E (0.70) KDM4EPOLBALDH1A1HPGDGAA
SCHEMBL17324741 0.79 HRH4 (0.61) KDM4EPOLBALDH1A1HRH4RAB9A
SCHEMBL6410488 0.78 KDM4E (0.53) KDM4EPOLBALDH1A1HPGDGAA
Bromide SCHEMBL4181830 0.78 KDM4E (0.68) KDM4EPOLBALDH1A1HPGDGAA
SCHEMBL16039101 0.78 KDM4E (0.60) KDM4EPOLBALDH1A1HPGDGAA
SCHEMBL7981086 0.78 KDM4E (0.44) KDM4EPOLBALDH1A1HPGDHRH4
SCHEMBL1445451 0.77 KDM4E (1.00) KDM4EPOLBALDH1A1HPGDGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4719382-A1 INHIBITORS OF TYPE 1 METHIONYL-TRNA SYNTHETASE AND METHODS OF USING THEM University of Washington (US) 2026-04-08 — — EP disclosed
EP-4701635-A1 1,2,4-TRIAZOLE-3-THIONE INHIBITORS OF TREX2 FOR USE IN THE TREATMENT OF PSORIASIS, ATOPIC DERMATITIS OR ICHTHYOSIS Universitat De Barcelona (ES) 2026-03-04 — — EP disclosed
EP-4076460-B1 1,4-DIHYDRO-2H-SPIRO[ISOQUINOLINE-3,4'-PIPERIDINE DERIVATIVES AS PRMT5 INHIBITORS FOR THE TREATMENT OF CANCER MERCK SHARP & DOHME LLC (US) 2026-01-21 — — EP disclosed
US-12441730-B2 PRMT5 inhibitors MERCK SHARP & DOHME LLC (US) 2025-10-14 — — US disclosed
EP-4077306-B1 COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2025-05-07 — — EP disclosed
WO-2024242729-A1 INHIBITORS OF TYPE 1 METHIONYL-TRNA SYNTHETASE AND METHODS OF USING THEM UNIVERSITY OF WASHINGTON (US) 2024-11-28 — — WO disclosed
WO-2024223907-A1 1,2,4-TRIAZOLE-3-THIONE INHIBITORS OF TREX2 FOR USE IN THE TREATMENT OF PSORIASIS, ATOPIC DERMATITIS OR ICHTHYOSIS UNIVERSITAT DE BARCELONA (ES) 2024-10-31 — — WO disclosed
CN-116730995-B Hydrazide compound, preparation method and application thereof 深圳微芯生物科技股份有限公司 2024-06-25 — — CN disclosed
US-11992535-B2 Compounds and probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2024-05-28 — — US disclosed
CN-111542523-B Heterocyclic compounds as PRMT5 inhibitors 朱比连特埃皮斯科瑞有限责任公司 2024-03-29 — — CN disclosed
US-20040132708-A1 Process for preparing 6-alkylidene penem derivatives WYETH 2004-07-08 — — US disclosed
US-20040077622-A1 Bicyclic 5-alkylidene-penems as beta lactamases inhibitors WYETH 2004-04-22 — — US disclosed
US-20040053913-A1 Process for preparing 6-alkylidene penem derivatives WYETH 2004-03-18 — — US disclosed
WO-2003093279-A1 BICYCLIC 6-ALKYLIDENE-PENEMS AS ß-LACTAMASES INHIBITORS WYETH (US) 2003-11-13 — — WO disclosed
WO-2003093277-A1 PROCESS FOR PREPARING 6-ALKYLIDENE PENEM DERIVATIVES WYETH (US) 2003-11-13 — — WO disclosed
US-5028605-A Antispasmodic, bronchodilators, uterine relaxants, cardiac analeptics, neurosedatives L'UNIVERSITE DE MONTPELLIER I (FR) 1991-07-02 — — US disclosed
EP-0348392-A1 8-ALKYLAMINOIMIDAZO[1,2-A]PYRAZINES AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY Université Montpellier I (FR) 1990-01-03 — — EP disclosed
WO-1988004298-A1 8-ALKYLAMINOIMIDAZO[1,2-A]PYRAZINES AND DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1988-06-16 — — WO disclosed
EP-0231244-A1 6-ALKYLIDENE PENEMS BEECHAM GROUP PLC (GB) 1987-08-12 — — EP disclosed
WO-1987000525-A1 6-ALKYLIDENE PENEMS BEECHAM GROUP P.L.C. (GB) 1987-01-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040132708-A1 Process for preparing 6-alkylidene penem derivatives PGM2, BPGM, MRPL21 KDM4E 1977/4885POLB 338/4885ALDH1A1 998/4885
US-20040053913-A1 Process for preparing 6-alkylidene penem derivatives PGM2, BPGM, MRPL21 KDM4E 1977/4885POLB 338/4885ALDH1A1 998/4885
US-20040077622-A1 Bicyclic 5-alkylidene-penems as beta lactamases inhibitors PGLS, BPGM, B2M KDM4E 957/4885POLB 453/4885ALDH1A1 426/4885
US-11992535-B2 Compounds and probes for imaging huntingtin protein HTT, HYPK, HSPBP1 KDM4E 4698/4885POLB 3910/4885ALDH1A1 4528/4885
US-12441730-B2 PRMT5 inhibitors PRMT5, PRMT1, PRMT3 KDM4E 61/4885POLB 1640/4885ALDH1A1 1341/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.