Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 3/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.57 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL2927275 | 0.85 | AGTR2 (0.58) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL683371 | 0.85 | AGTR2 (0.78) | AGTR2AGTR1 | |
| Potassium SCHEMBL3033376 | 0.84 | AGTR2 (0.77) | AGTR2AGTR1 | |
| SCHEMBL2927273 | 0.84 | AGTR2 (0.77) | AGTR2AGTR1 | |
| SCHEMBL2132264 | 0.84 | AGTR2 (0.63) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL10298805 | 0.82 | AGTR2 (0.57) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL5548451 | 0.79 | AGTR2 (0.67) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL15702902 | 0.76 | AGTR2 (0.83) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL15644523 | 0.75 | AGTR2 (0.78) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL683650 | 0.75 | AGTR2 (0.87) | AGTR2AGTR1ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172401-A1 | BENZIMIDAZOLE DERIVATIVE AND USE AS ANGIOTENSIN II ANTAGONIST | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2012-07-05 | — | — | US | disclosed |
| EP-1863801-B1 | BENZIMIDAZOLE DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2010-09-29 | — | — | EP | disclosed |
| US-20090054502-A1 | Benzimidazole Derivative and Use as Angiotensin II Antagonist | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172401-A1 | BENZIMIDAZOLE DERIVATIVE AND USE AS ANGIOTENSIN II ANTAGONIST | AGTR2, AGTR1, ACE | AGTR1 2/4885AGTR2 1/4885ABCC3 1292/4885 |
| US-20090054502-A1 | Benzimidazole Derivative and Use as Angiotensin II Antagonist | AGTR2, AGTR1, ACE | AGTR1 2/4885AGTR2 1/4885ABCC3 1292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.