Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931742 | 0.92 | MEN1 (0.38) | MEN1KMT2AADORA2BADORA2AADORA1 | |
| SCHEMBL1760930 | 0.89 | FAAH (0.45) | MEN1KMT2AADORA2BADORA2AADORA1 | |
| SCHEMBL2932137 | 0.88 | CCR3 (0.42) | MEN1KMT2AHCAR1GPR6 | |
| SCHEMBL2932276 | 0.87 | CYP2D6 (0.41) | ADORA2BADORA2AADORA1 | |
| SCHEMBL2927982 | 0.87 | ADORA2B (0.47) | MEN1KMT2AADORA2BADORA2AADORA1 | |
| SCHEMBL2927088 | 0.86 | GPR6 (0.41) | MEN1KMT2ATP53MAPTGPR6 | |
| SCHEMBL2932134 | 0.86 | PPARD (0.42) | PIK3CDGPR6 | |
| SCHEMBL2924971 | 0.85 | CCR3 (0.40) | HCAR1LPAR2 | |
| SCHEMBL2930809 | 0.84 | LMNA (0.40) | MEN1KMT2AADORA2AADORA1MAPT | |
| SCHEMBL2931360 | 0.84 | GPR6 (0.47) | ADORA2BADORA2AADORA1GPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |