Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29314851 | 0.89 | ADORA3 (0.36) | ADORA2AADORA3ADORA1TLR7TLR8 | |
| SCHEMBL29314607 | 0.83 | ADORA2B (0.42) | ADORA2AADORA3ADORA1TLR7TLR8 | |
| SCHEMBL23037577 | 0.83 | TLR8 (0.43) | ADORA2AADORA3ADORA1TLR7TLR8 | |
| SCHEMBL29315565 | 0.82 | TLR7 (0.38) | ADORA2AADORA3ADORA1TLR7TLR8 | |
| SCHEMBL23037627 | 0.82 | TLR8 (0.47) | ADORA2AADORA3ADORA1TLR7TLR8 | |
| SCHEMBL29314853 | 0.81 | NOS3 (0.35) | TLR7TLR8 | |
| SCHEMBL23037675 | 0.81 | TLR7 (0.46) | ADORA2AADORA3ADORA1TLR7TLR8 | |
| SCHEMBL30539860 | 0.81 | TLR7 (0.46) | ADORA2AADORA3ADORA1TLR7TLR8 | |
| SCHEMBL29315533 | 0.81 | MPO (0.38) | ADORA2AADORA3ADORA1TLR7TLR8 | |
| SCHEMBL29314863 | 0.80 | TLR8 (0.35) | ADORA2AADORA3ADORA1TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12037344-B2 | NLRP3 modulators | INNATE TUMOR IMMUNITY, INC (US) | 2024-07-16 | — | — | US | disclosed |
| US-12037344-B2 | NLRP3 modulators | INNATE TUMOR IMMUNITY, INC (US) | 2024-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12037344-B2 | NLRP3 modulators | NLRP3, NLRP1, PYCARD | ADORA2A 459/4885ADORA3 956/4885ADORA1 429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.