Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11625767 | 0.98 | KDM4E (0.44) | KDM4EKMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL13176559 | 0.82 | KDM4E (0.37) | KDM4EKMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL11625625 | 0.77 | KDM4E (0.54) | KDM4EKMT2ANUAK1IGF1RMET | |
| SCHEMBL12444323 | 0.72 | KDM4E (0.45) | KDM4EKMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL16870479 | 0.71 | KDM4E (0.47) | KDM4EKMT2AMEN1NUAK1IGF1R | |
| SCHEMBL6062280 | 0.68 | NUAK1 (0.41) | KDM4EKMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL9606823 | 0.68 | NUAK1 (0.41) | KDM4EKMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL30048869 | 0.68 | KDM4E (0.44) | KDM4EGAASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL15680616 | 0.67 | KDM4E (0.46) | KDM4EKMT2AMEN1NUAK1IGF1R | |
| SCHEMBL23857115 | 0.66 | ALDH1A1 (0.40) | KDM4EKMT2AMEN1NUAK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5421337-A | To determine the presence of abnormal tissue | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1995-06-06 | — | — | US | claimed |
| CN-119601089-A | Urine endogenous metabolism marker and application thereof | 中国人民解放军海军军医大学第二附属医院 | 2025-03-11 | — | — | CN | disclosed |
| EP-2230312-A1 | Probe compound for detecting and isolating enzymes and means and methods using the same | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2010-09-22 | — | — | EP | disclosed |
| US-20080311099-A1 | Pyridoxal-5-Phosphate and Related Compounds in Combination With Therapeutic Cardiovascular Compounds for Treating Angina | MEDICURE INTERNATIONAL INC. | 2008-12-18 | — | — | US | disclosed |
| WO-2007121588-A1 | TREATMENT OF ATRIAL FIBRILLATION | MEDICURE INTERNATIONAL INC. (BB) | 2007-11-01 | — | — | WO | disclosed |
| US-20070249562-A1 | TREATMENT OF ATRIAL FIBRILLATION | MEDICURE INTERNATIONAL INC. (CA) | 2007-10-25 | — | — | US | disclosed |
| US-20070167411-A1 | Compositions for treating angina | MEDICURE INTERNATIONAL INC. (BB) | 2007-07-19 | — | — | US | disclosed |
| US-20070032456-A1 | Modulation of cell death | MEDICURE INC. (CA) | 2007-02-08 | — | — | US | disclosed |
| JP-2006238808-A | NEW PYRIDOXAL 4-DEHYDROGENASE AND ITS UTILIZATION | KOCHI UNIV | 2006-09-14 | — | — | JP | disclosed |
| EP-1610783-A2 | MODULATION OF CELL DEATH | Medicure Inc. (CA) | 2006-01-04 | — | — | EP | disclosed |
| EP-1608379-A1 | COMPOSITIONS FOR TREATING ANGINA | Medicure Inc. (CA) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004084910-A1 | COMPOSITIONS FOR TREATING ANGINA | MEDICURE INC. (CA) | 2004-10-07 | — | — | WO | disclosed |
| WO-2004084895-A2 | MODULATION OF CELL DEATH | MEDICURE, INC. (CA) | 2004-10-07 | — | — | WO | disclosed |
| US-5421337-A | To determine the presence of abnormal tissue | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1995-06-06 | — | — | US | disclosed |
| EP-0466828-A1 | SPECTRAL DIAGNOSIS OF DISEASED TISSUE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1992-01-22 | — | — | EP | disclosed |
| WO-1990012536-A1 | SPECTRAL DIAGNOSIS OF DISEASED TISSUE | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1990-11-01 | — | — | WO | disclosed |
| US-4070450-A | Sunscreening compound and method | HOFFMANN-LA ROCHE, INC. (US) | 1978-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249562-A1 | TREATMENT OF ATRIAL FIBRILLATION | PNPO, KCNH1, PLPBP | KDM4E 1940/4885KMT2A 3014/4885MEN1 2331/4885 |
| US-20070167411-A1 | Compositions for treating angina | PNPO, PYGM, PLPBP | KDM4E 2123/4885KMT2A 3440/4885MEN1 3967/4885 |
| US-20080311099-A1 | Pyridoxal-5-Phosphate and Related Compounds in Combination With Therapeutic Cardiovascular Compounds for Treating Angina | ALOX5, PNPO, KCNMB1 | KDM4E 1392/4885KMT2A 2206/4885MEN1 4725/4885 |
| US-20070032456-A1 | Modulation of cell death | CASP6, CASP3, CASP5 | KDM4E 1592/4885KMT2A 4133/4885MEN1 3529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.