Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21756736 | 0.88 | ROCK2 (0.58) | ROCK2ROCK1HPGDALDH1A1KMT2A | |
| SCHEMBL31013604 | 0.88 | ROCK2 (0.58) | ROCK2ROCK1HPGDALDH1A1KMT2A | |
| SCHEMBL21756739 | 0.75 | MMP13 (0.62) | ROCK2ROCK1HPGDALDH1A1KMT2A | |
| SCHEMBL29328528 | 0.74 | MMP13 (0.60) | ROCK2HPGDALDH1A1MAOBKDM4E | |
| SCHEMBL29328536 | 0.74 | ALDH1A1 (0.47) | ALDH1A1KMT2AMAPTTP53 | |
| SCHEMBL21756738 | 0.74 | HPGD (0.55) | HPGDALDH1A1KMT2AMAPTNPC1 | |
| SCHEMBL29328527 | 0.73 | KMT2A (0.52) | HPGDALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL4893856 | 0.73 | MTNR1A (0.40) | ROCK2ROCK1HPGDALDH1A1KMT2A | |
| SCHEMBL14057374 | 0.72 | TAS1R3 (0.60) | ALDH1A1KMT2ANPC1TP53KDM4E | |
| SCHEMBL6660067 | 0.71 | MTNR1A (0.57) | ALDH1A1KMT2ANPC1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043601-B2 | N-substituted-1H-1,2,4-triazole-3-carboxamides, analogues thereof, and methods of treatment using same | THE REGENTS OF THE UNIVERSITY OF COLORADO (US) | 2024-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12043601-B2 | N-substituted-1H-1,2,4-triazole-3-carboxamides, analogues thereof, and methods of treatment using same | BAK1, NAAA, CASP3 | ROCK2 1623/4885ROCK1 1436/4885HPGD 2807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.