Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 11/20 | 0.41 |
| ▸ | BCHE | P06276 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3050426 | 0.91 | BCHE (0.42) | ACHEBCHEHTTRORCDHODH | |
| SCHEMBL1761071 | 0.88 | FAAH (0.42) | ACHEBCHEMAPTHTTPKM | |
| SCHEMBL2929411 | 0.85 | ADORA2A (0.41) | ACHEMAPTHTTKDM4EALDH1A1 | |
| SCHEMBL2931169 | 0.85 | OGA (0.38) | ACHELMNA | |
| SCHEMBL2930746 | 0.84 | ACHE (0.40) | ACHEBCHEMAPTALDH1A1 | |
| SCHEMBL2930557 | 0.84 | HTT (0.38) | MAPTHTTALDH1A1LMNA | |
| SCHEMBL2932222 | 0.84 | KDM4E (0.38) | KDM4EALDH1A1 | |
| SCHEMBL2930504 | 0.83 | FAAH (0.45) | MAPTHTTKDM4EALDH1A1LMNA | |
| SCHEMBL2930809 | 0.83 | LMNA (0.40) | ACHEMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL3049811 | 0.83 | MEN1 (0.42) | ACHEMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |