Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.42 |
| ▸ | ACHE | P22303 | 4/20 | 0.42 |
| ▸ | GPR6 | P46095 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2934358 | 0.91 | ACHE (0.41) | BCHEACHERORCDHODHHTT | |
| SCHEMBL1760988 | 0.88 | BCHE (0.43) | BCHEACHEGPR6ADORA3ADORA2A | |
| SCHEMBL2930746 | 0.86 | ACHE (0.40) | BCHEACHEGPR6ADORA2AADORA1 | |
| SCHEMBL2929411 | 0.85 | ADORA2A (0.41) | ACHEADORA3ADORA2AADORA1MEN1 | |
| SCHEMBL2932222 | 0.85 | KDM4E (0.38) | GPR6ADORA3ADORA2AADORA1MEN1 | |
| SCHEMBL2931169 | 0.84 | OGA (0.38) | ACHEGPR6ADORA2AADORA1MEN1 | |
| SCHEMBL3049811 | 0.84 | MEN1 (0.42) | ACHEADORA2AMEN1KMT2ALPAR2 | |
| SCHEMBL2930557 | 0.83 | HTT (0.38) | ADORA3ADORA2AADORA1MEN1KMT2A | |
| SCHEMBL2930504 | 0.83 | FAAH (0.45) | GPR6MEN1KMT2ATSHRHTT | |
| SCHEMBL2930809 | 0.82 | LMNA (0.40) | ACHEADORA3ADORA2AADORA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027132-B1 | THIAZOLO-PYRAMIDINE / PYRIDINE UREA DERIVATIVES AS ADENOSINE A2B RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-09-15 | — | — | EP | claimed |