SCHEMBL29358798

SCHEMBL29358798

[O-][n+]1ccc2ccccc2c1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACHE P22303 14/20 0.46
BCHE P06276 13/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL232638 1.00 ACHE (0.46) ACHEBCHE
Methyl Alcohol SCHEMBL9624379 0.93 ACHE (0.42) ACHEBCHE
SCHEMBL9902394 0.85 ATM (0.44) ACHEBCHE
Isoquinoline SCHEMBL5264460 0.82 ACHE (0.37) ACHEBCHE
SCHEMBL13659534 0.77 ALDH1A1 (0.52)
SCHEMBL5894087 0.71 CYP2A6 (0.44) ACHEBCHE
SCHEMBL25252937 0.70 CYP1A2 (0.52)
SCHEMBL31426083 0.70 CYP2A6 (0.46) ACHE
SCHEMBL31228277 0.70 CYP1A2 (0.46) ACHE
SCHEMBL23088139 0.70 CYP2A6 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12605450-B2 C3-carbon linked glutarimide Degronimers for target protein degradation C4 THERAPEUTICS, INC. (US) 2026-04-21 US disclosed
US-20250059209-A1 THERAPEUTIC AGENTS AND USES THEREOF ANKH LIFE SCIENCES LIMITED (IE) 2025-02-20 US disclosed
US-20240398959-A1 C3-CARBON LINKED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION C4 THERAPEUTICS, INC. (US) 2024-12-05 US disclosed
US-12129265-B2 Therapeutic agents and uses thereof ANKH LIFE SCIENCES LIMITED (IE) 2024-10-29 US disclosed
CN-111447931-B Anticancer/antifibrotic compounds 加利福尼亚大学董事会 2024-01-26 CN disclosed
EP-4185288-A1 THERAPEUTIC AGENTS AND USES THEREOF Ankh Life Sciences Limited (IE) 2023-05-31 EP disclosed
US-20230159504-A1 7- OR 8-HYDROXY-ISOQUINOLINE AND 7- OR 8-HYDROXY-QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD) VERTEX PHARMACEUTICALS INCORPORATED 2023-05-25 US disclosed
CN-112574107-B Synthesis method of atropisomeric 1-arylisoquinoline N-oxide and derivatives thereof 浙江工业大学 2023-04-07 CN disclosed
US-20220313826-A1 C3-CARBON LINKED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION C4 THERAPEUTICS, INC. (US) 2022-10-06 US disclosed
CN-114423757-A Tricyclic heteroaryl compounds useful as IRAK4 inhibitors 百时美施贵宝公司 2022-04-29 CN disclosed
US-20220033417-A1 THERAPEUTIC AGENTS AND USES THEREOF ANKH LIFE SCIENCES LIMITED (IE) 2022-02-03 US disclosed
WO-2022019892-A1 THERAPEUTIC AGENTS AND USES THEREOF ANKH LIFE SCIENCES LIMITED (IE) 2022-01-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12605450-B2 C3-carbon linked glutarimide Degronimers for target protein degradation NEDD4, UBE3A, UBE3C ACHE 4845/4885BCHE 4228/4885
US-20250059209-A1 THERAPEUTIC AGENTS AND USES THEREOF MCL1, RNASE1, HNMT ACHE 663/4885BCHE 1254/4885
US-20240398959-A1 C3-CARBON LINKED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION STUB1, UBE3C, UBE3A ACHE 4785/4885BCHE 3186/4885
US-20220313826-A1 C3-CARBON LINKED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION STUB1, UBE3C, UBE3A ACHE 4785/4885BCHE 3186/4885
US-12129265-B2 Therapeutic agents and uses thereof MCL1, BCL9, RNASE1 ACHE 688/4885BCHE 1153/4885
US-20230159504-A1 7- OR 8-HYDROXY-ISOQUINOLINE AND 7- OR 8-HYDROXY-QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD) SERPINA2, SERPINB1, SERPINE1 ACHE 1777/4885BCHE 1601/4885
US-20220033417-A1 THERAPEUTIC AGENTS AND USES THEREOF MCL1, BCL9, RNASE1 ACHE 688/4885BCHE 1153/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.