Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Eclanamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.40 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.40 |
| ▸ | MTOR known ✓ | P42345 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eclanamine SCHEMBL124915 | 1.00 | SLC6A4 (0.40) | SLC6A4SLC6A2SLC6A3OPRD1OPRK1 | |
| Eclanamine SCHEMBL11446626 | 0.93 | OPRK1 (0.41) | SLC6A4OPRD1OPRK1SIGMAR1OPRM1 | |
| Eclanamine SCHEMBL2109152 | 0.93 | OPRK1 (0.41) | SLC6A4OPRD1OPRK1SIGMAR1OPRM1 | |
| Eclanamine SCHEMBL29388487 | 0.93 | OPRK1 (0.41) | SLC6A4OPRD1OPRK1SIGMAR1OPRM1 | |
| SCHEMBL11443857 | 0.81 | TACR1 (0.41) | SLC6A4OPRD1OPRK1SIGMAR1OPRM1 | |
| SCHEMBL11443856 | 0.81 | TACR1 (0.41) | SLC6A4OPRD1OPRK1SIGMAR1OPRM1 | |
| SCHEMBL11447020 | 0.81 | OPRD1 (0.42) | OPRD1OPRK1SIGMAR1OPRM1ALDH1A1 | |
| SCHEMBL11498170 | 0.81 | TACR1 (0.44) | SLC6A4OPRD1OPRK1SIGMAR1OPRM1 | |
| Fumaric Acid SCHEMBL11447589 | 0.77 | ALDH1A1 (0.37) | SLC6A4SLC6A2SIGMAR1CYP3A4ALDH1A1 | |
| SCHEMBL11378463 | 0.77 | TACR1 (0.44) | SLC6A4SLC6A3OPRD1OPRK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113993522-A | Method for treating anxiety disorders, headache disorders and eating disorders with siloxibin | 指南针探路者有限公司 | 2022-01-28 | — | — | CN | disclosed |