Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 0.81 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.81 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+)-Menthol SCHEMBL10072505 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Racementhol SCHEMBL521946 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL12646785 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+) Neomenthol SCHEMBL260049 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL9968934 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL15449169 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL13059620 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Isomenthol SCHEMBL677675 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL20771511 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL1709231 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6916463-B2 | Oral products having an aesthetic layer | THE PROCTER & GAMBLE COMPANY (US) | 2005-07-12 | — | — | US | claimed |
| US-20040057910-A1 | Oral products having an aesthetic layer | THE PROCTER & GAMBLECOMPANY | 2004-03-25 | — | — | US | claimed |
| CN-101909582-A | Oral care delivery system with microcrystalline wax | PROCTER & GAMBLE | 2010-12-08 | — | — | CN | disclosed |
| EP-2227214-A1 | ORAL CARE DELIVERY SYSTEM WITH MICROCRYSTALLINE WAX | The Procter & Gamble Company (US) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009090566-A1 | ORAL CARE DELIVERY SYSTEM WITH MICROCRYSTALLINE WAX | THE PROCTER & GAMBLE COMPANY (US) | 2009-07-23 | — | — | WO | disclosed |
| US-20090181071-A1 | Oral Care Delivery System with Microcrystalline Wax | THE PROCTER & GAMBLE COMPANY | 2009-07-16 | — | — | US | disclosed |
| EP-1542649-B1 | ORAL PRODUCTS HAVING AN AESTHETIC LAYER | PROCTER & GAMBLE (US) | 2008-04-30 | — | — | EP | disclosed |
| US-6916463-B2 | Oral products having an aesthetic layer | THE PROCTER & GAMBLE COMPANY (US) | 2005-07-12 | — | — | US | disclosed |
| EP-1542649-A1 | ORAL PRODUCTS HAVING AN AESTHETIC LAYER | THE PROCTER & GAMBLE COMPANY (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004028499-A1 | ORAL PRODUCTS HAVING AN AESTHETIC LAYER | THE PROCTER & GAMBLE COMPANY (US) | 2004-04-08 | — | — | WO | disclosed |
| US-20040057910-A1 | Oral products having an aesthetic layer | THE PROCTER & GAMBLECOMPANY | 2004-03-25 | — | — | US | disclosed |
| EP-0725630-A1 | FAST DISSOLVING DOSAGE FORMS CONTAINING MAGNESIUM ALUMINUM SILICATE AND MULTIPLE ACTIVE INGREDIENTS | THE PROCTER & GAMBLE COMPANY (US) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995011671-A1 | FAST DISSOLVING DOSAGE FORMS CONTAINING MAGNESIUM ALUMINUM SILICATE AND MULTIPLE ACTIVE INGREDIENTS | THE PROCTER & GAMBLE COMPANY (US) | 1995-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181071-A1 | Oral Care Delivery System with Microcrystalline Wax | MCRS1, TAS2R39, MRPS27 | TRPM8 3970/4885TRPA1 3423/4885EPHX1 946/4885 |
| US-20040057910-A1 | Oral products having an aesthetic layer | CUTA, LPL, SUCLG1 | TRPM8 2892/4885TRPA1 2710/4885EPHX1 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.