Oxametacin

Oxametacin

SCHEMBL29378857

COc1ccc2c(c1)c(CC(=O)NO)c(C)n2C(=O)c1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTGS1 P23219 3/20 1.00
▸ PTGS2 P35354 12/20 0.85
▸ AKR1C3 P42330 3/20 0.81
▸ CNR2 P34972 1/20 0.81
▸ MAPT P10636 3/20 0.80
▸ KMT2A Q03164 2/20 0.80
▸ NPSR1 Q6W5P4 2/20 0.80
▸ AKR1C2 P52895 2/20 0.79
▸ KDM4E B2RXH2 1/20 0.79
▸ MEN1 O00255 1/20 0.79
▸ PTGES O14684 1/20 0.79
▸ ABCC3 O15438 1/20 0.79
▸ ABCC4 O15439 1/20 0.79
▸ ABCB11 O95342 1/20 0.79
▸ MT-CO2 P00403 1/20 0.79
▸ LMNA P02545 1/20 0.79
▸ ALB P02768 1/20 0.79
▸ CYP1A2 P05177 1/20 0.79
▸ ABCB1 P08183 1/20 0.79
▸ ALOX5 P09917 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxametacin SCHEMBL24552 1.00 PTGS1 (1.00) PTGS1PTGS2AKR1C3CNR2MAPT
SCHEMBL14405006 0.92 PTGS2 (1.00) PTGS1PTGS2AKR1C3CNR2MAPT
SCHEMBL20259394 0.91 PTGS2 (0.83) PTGS1PTGS2AKR1C3CNR2MAPT
SCHEMBL9657228 0.91 PTGS1 (0.85) PTGS1PTGS2AKR1C3CNR2MAPT
SCHEMBL14398315 0.90 PTGS1 (0.82) PTGS1PTGS2AKR1C3CNR2MAPT
SCHEMBL5107049 0.90 PTGS2 (0.82) PTGS1PTGS2AKR1C3CNR2MAPT
SCHEMBL5112013 0.90 PTGS2 (0.84) PTGS1PTGS2
SCHEMBL30426824 0.89 PTGS2 (1.00) PTGS1PTGS2AKR1C3CNR2MAPT
SCHEMBL14086813 0.89 PTGS2 (1.00) PTGS1PTGS2AKR1C3CNR2MAPT
SCHEMBL17378074 0.89 PTGS2 (0.80) PTGS1PTGS2AKR1C3CNR2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 316 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4628080-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRUG-RELATED PEPTIC ULCER COMPRISING ZASTAPRAZAN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF Jeil Pharmaceutical Co., Ltd. (KR) 2025-10-08 — — EP claimed
US-20250041208-A1 NEW INJECTABLE COMBINATION FORMULATION NANEXA AB (SE) 2025-02-06 — — US claimed
EP-3508501-B1 USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO PREVENT OR INHIBIT PHOTOPHOBIA OR LIGHT AVERSION IN SUBJECTS IN NEED THEREOF, ESPECIALLY MIGRAINE SUFFERERS H LUNDBECK AS (DK) 2024-11-06 — — EP claimed
EP-4444277-A1 NEW INJECTABLE COMBINATION FORMULATION Nanexa AB (SE) 2024-10-16 — — EP claimed
CN-118647367-A Novel injectable combination formulations 南爱克萨股份公司 2024-09-13 — — CN claimed
WO-2024117797-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRUG-RELATED PEPTIC ULCER COMPRISING ZASTAPRAZAN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF 제일약품 주식회사 2024-06-06 — — WO claimed
WO-2024105529-A1 CHEMICAL DISBUDDING OF LIVESTOCK MASSEY UNIVERSITY (NZ) 2024-05-23 — — WO claimed
EP-4340884-A1 TREATMENT OF INFECTIONS IN AND AROUND THE EYE University of Miami (US) 2024-03-27 — — EP claimed
US-20230346820-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 THE SCRIPPS RESEARCH INSTITUTE 2023-11-02 — — US claimed
WO-2023105227-A1 NEW INJECTABLE COMBINATION FORMULATION NANEXA AB (SE) 2023-06-15 — — WO claimed
WO-2022245950-A1 TREATMENT OF INFECTIONS IN AND AROUND THE EYE UNIVERSITY OF MIAMI (US) 2022-11-24 — — WO claimed
US-20220117921-A1 PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF PAIN IMUNEKS FARMA ILAC SANAYI VE TICARET A.S. (TR) 2022-04-21 — — US claimed
US-20260125335-A1 SYNTHETIC CANNABINOID ANALOGS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF TREATING BACTERIAL INFECTIONS AND OTHER DISORDERS MIRALOGX LLC (US) 2026-05-07 — — US disclosed
EP-3938345-B1 CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE NOCION THERAPEUTICS INC (US) 2026-05-06 — — EP disclosed
US-20260116859-A1 Charged Ion Channel Blockers and Methods for Use NOCION THERAPEUTICS INC (US) 2026-04-30 — — US disclosed
US-20260117177-A1 T-CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS DARTMOUTH COLLEGE (US) 2026-04-30 — — US disclosed
EP-3952882-A1 IMMUNOMODULATORY OLIGOSACCHARIDES FOR THE TREATMENT OF PAIN Intrinsic Medicine, Inc. (US) 2022-02-16 — — EP disclosed
US-20220040309-A1 COMPOSITIONS WITH PERMEATION ENHANCERS FOR DRUG DELIVERY CHILDREN'S MEDICAL CENTER CORPORATION (US) 2022-02-10 — — US disclosed
US-20220041552-A1 CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2022-02-10 — — US disclosed
US-20220040102-A1 Solid Solution Compositions and Use in Chronic Inflammation INFIRST HEALTHCARE LIMITED (GB) 2022-02-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220041552-A1 CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE TRPV1, TRPV2, TRPA1 PTGS1 478/4885PTGS2 465/4885AKR1C3 2430/4885
US-20260117177-A1 T-CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS ICOS, CD4, CD2 PTGS1 4491/4885PTGS2 4390/4885AKR1C3 4264/4885
US-20260116859-A1 Charged Ion Channel Blockers and Methods for Use OPRL1, TRPV1, SCN2B PTGS1 642/4885PTGS2 689/4885AKR1C3 506/4885
US-20230346820-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF SARS-COV-2 ACE2, SARS1, ACE PTGS1 1329/4885PTGS2 730/4885AKR1C3 1800/4885
US-20260125335-A1 SYNTHETIC CANNABINOID ANALOGS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF TREATING BACTERIAL INFECTIONS AND OTHER DISORDERS CNR1, CNR2, FAAH PTGS1 1674/4885PTGS2 2183/4885AKR1C3 895/4885
US-20220040309-A1 COMPOSITIONS WITH PERMEATION ENHANCERS FOR DRUG DELIVERY ABCB11, MMP1, SLC47A1 PTGS1 13/4885PTGS2 63/4885AKR1C3 1901/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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