Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 6/20 | 0.40 |
| ▸ | CES2 | O00748 | 5/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.37 |
| ▸ | FABP3 | P05413 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2940726 | 1.00 | CA1 (0.41) | CA1CES1CES2TRPA1ATM | |
| Fumaric Acid SCHEMBL1579070 | 0.91 | CES2 (0.44) | CES1CES2FABP3 | |
| Fumaric Acid SCHEMBL1579076 | 0.91 | CES2 (0.44) | CES1CES2FABP3 | |
| Fumaric Acid SCHEMBL27580575 | 0.86 | FABP3 (0.43) | CA1CES1CES2FABP3 | |
| Ethyl Fumarate SCHEMBL11242272 | 0.85 | HCAR2 (0.48) | CA1ATM | |
| Ethyl Fumarate SCHEMBL11242282 | 0.85 | HCAR2 (0.48) | CA1ATM | |
| Acrylic Acid SCHEMBL11582286 | 0.84 | TSHR (0.42) | CA1CES1CES2FABP3 | |
| Butyl Fumarate SCHEMBL11121036 | 0.84 | ATM (0.67) | ATM | |
| SCHEMBL10833587 | 0.82 | CASP1 (0.34) | CA1CES1CES2TRPA1ATM | |
| Acetic Acid SCHEMBL674467 | 0.82 | CES1 (0.46) | CA1CES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119463159-A | Silanized polyphenyl ether resin and preparation method thereof, high-temperature-resistant low-dielectric material and preparation method thereof | 北京化工大学 | 2025-02-18 | — | — | CN | claimed |
| CN-119410019-A | Hard chlorinated polyvinyl chloride foaming material and preparation method thereof | 山东高信化学股份有限公司 | 2025-02-11 | — | — | CN | claimed |
| CN-118675804-A | Smooth copper sheath fireproof cable with excellent moisture resistance and preparation method | 浙江万马股份有限公司 | 2024-09-20 | — | — | CN | claimed |
| CN-115135632-B | Preparation method of ester compound | 韩华思路信(株) | 2024-03-29 | — | — | CN | claimed |
| US-20230078583-A1 | PREPARATION METHOD OF ESTER COMPOUND | HANWHA SOLUTIONS CORPORAION (KR) | 2023-03-16 | — | — | US | claimed |
| EP-4105195-A1 | ESTER-BASED COMPOUND PRODUCTION METHOD | Hanwha Solutions Corporation (KR) | 2022-12-21 | — | — | EP | claimed |
| CN-114773747-A | Application of dihydropyridine polymer in preparation of PVC (polyvinyl chloride) material | 兰州金睿合新材料科技有限责任公司 | 2022-07-22 | — | — | CN | claimed |
| CN-114085642-A | Preparation method of organic silicon pressure-sensitive adhesive | 华烁科技股份有限公司 | 2022-02-25 | — | — | CN | claimed |
| CN-113292799-A | Transparent PVC-U electrical casing and preparation method thereof | 武汉市九牧管业科技有限公司 | 2021-08-24 | — | — | CN | claimed |
| WO-2021162284-A1 | ESTER-BASED COMPOUND PRODUCTION METHOD | 한화솔루션 주식회사 | 2021-08-19 | — | — | WO | claimed |
| EP-3688082-A1 | COMPOSITIONS COMPRISING A TIN-BASED CATALYST AND TITANIUM DIOXIDE FOR MOISTURE CURE OF SILANE-FUNCTIONALIZED ETHYLENIC POLYMERS | Dow Global Technologies LLC (US) | 2020-08-05 | — | — | EP | claimed |
| CN-110832008-A | Method for producing fatty acid monoesters of polyoxyethylene, esters produced thereby and use thereof | 沙特基础工业全球技术有限公司 | 2020-02-21 | — | — | CN | claimed |
| WO-2019067440-A1 | COMPOSITIONS COMPRISING A TIN-BASED CATALYST AND TITANIUM DIOXIDE FOR MOISTURE CURE OF SILANE-FUNCTIONALIZED ETHYLENIC POLYMERS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2019-04-04 | — | — | WO | claimed |
| CN-1506545-A | Flooring and wall covering based on concrete with antimicrobe purpose | 塞美克斯品牌环球有限公司 | 2004-06-23 | — | — | CN | claimed |
| US-5688890-A | Thermoplastic polyurethane composition | KURARAY CO., LTD. (JP) | 1997-11-18 | — | — | US | claimed |
| JP-60251155-A | — | — | None | — | — | JP | disclosed |
| US-20260138943-A1 | METHOD FOR PREPARING ESTER-BASED COMPOSITION | HANWHA SOLUTIONS CORP (KR) | 2026-05-21 | — | — | US | disclosed |
| US-4125533-A | STABILIZERS | SANKYO CO. LTD. (JP) | 1978-11-14 | — | — | US | disclosed |
| US-4016168-A | STABILIZERS FOR POLYMERS | SANKYO COMPANY LIMITED (JA) | 1977-04-05 | — | — | US | disclosed |
| US-3984371-A | PIPERIDINE DERIVATIVES | SANKYO COMPANY LIMITED (JA) | 1976-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260138943-A1 | METHOD FOR PREPARING ESTER-BASED COMPOSITION | NCEH1, ADH1A, TECR | CA1 3092/4885CES1 13/4885CES2 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.