Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL10528593 | 0.90 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL20187683 | 0.89 | MEN1 (0.77) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL6427079 | 0.89 | — | — | |
| Tromethamine SCHEMBL14735910 | 0.85 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL11881550 | 0.85 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL17484 | 0.84 | MEN1 (1.00) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL3696191 | 0.84 | — | — | |
| Tromethamine SCHEMBL975 | 0.84 | — | — | |
| Tromethamine SCHEMBL7091147 | 0.81 | — | — | |
| Tromethamine SCHEMBL2035496 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112812489-A | Modified plastic based on interpenetrating network structure and preparation method thereof | 浙江科普特新材料有限公司 | 2021-05-18 | — | — | CN | claimed |
| CN-112812410-A | Dynamic vulcanization TPV composite material based on interpenetrating polymer network structure and preparation method thereof | 浙江科普特新材料有限公司 | 2021-05-18 | — | — | CN | claimed |
| CN-108478802-B | High-stability combined drug delivery system for cancer treatment and construction method | 浙江工业大学 | 2020-05-22 | — | — | CN | claimed |
| CN-115521463-A | Trifluoromethyl organosilicon alicyclic epoxy monomer and preparation and application thereof | 湖北固润科技股份有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-115403336-A | Curing agent for filling full-tailing slag prepared from lead-zinc tailings and application thereof | 厦门兑泰新材料科技有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-115403622-A | Method for separating and purifying trihydroxymethyl phosphorus by polysaccharide macromolecular hydroxyl compound | 上海应用技术大学 | 2022-11-29 | — | — | CN | disclosed |
| CN-115260896-A | Preparation and application of transparent scratch-resistant nanocellulose/ceramic/siloxane flexible hard coating | 华南理工大学 | 2022-11-01 | — | — | CN | disclosed |
| CN-111377916-B | Organic compound having improved light emitting characteristics, organic light emitting diode having the same, and organic light emitting device | 乐金显示有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-115124541-A | Preparation and application of IDO1 inhibitor | 中国医学科学院药物研究所 | 2022-09-30 | — | — | CN | disclosed |
| CN-113880866-B | Aza-tetrahydronaphthyridine compound, preparation method thereof, pharmaceutical composition and application thereof | 上海维申医药有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-111013638-B | ZnFe 2 O 4 Preparation method of/SBA-15 nano composite material | 齐齐哈尔大学 | 2022-09-20 | — | — | CN | disclosed |
| EP-3057416-A1 | STABLE COMPOSITION FOR CONTROLLING BIOLOGICAL GROWTH AND METHOD FOR USING SAME IN OIL FIELD APPLICATIONS | Lonza Inc. (US) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015057401-A1 | STABLE COMPOSITION FOR CONTROLLING BIOLOGICAL GROWTH AND METHOD FOR USING SAME IN OIL FIELD APPLICATIONS | LONZA INC. (US) | 2015-04-23 | — | — | WO | disclosed |
| US-20150105353-A1 | Stable Composition For Controlling Biological Growth and Method For Using Same in Oil Field Applications | Arxada, LLC | 2015-04-16 | — | — | US | disclosed |
| EP-2396170-B1 | METHODS FOR CONTROLLING DEPOLYMERIZATION OF POLYMER COMPOSITIONS | RHODIA OPERATIONS (FR) | 2015-03-25 | — | — | EP | disclosed |
| WO-2010093473-A1 | METHODS FOR CONTROLLING DEPOLYMERIZATION OF POLYMER COMPOSITIONS | RHODIA OPERATIONS (FR) | 2010-08-19 | — | — | WO | disclosed |
| EP-0380359-B1 | Biocidal compositions and treatments | ALBRIGHT & WILSON (GB) | 1993-12-29 | — | — | EP | disclosed |
| EP-0380359-A1 | Biocidal compositions and treatments | Albright & Wilson Limited (GB) | 1990-08-01 | — | — | EP | disclosed |
| US-4673509-A | ADDING PHOSPHONIUM COMPOUND | ALBRIGHT & WILSON LIMITED (GB) | 1987-06-16 | — | — | US | disclosed |
| EP-0139404-A1 | Biocidal water treatment | Albright & Wilson Limited (GB) | 1985-05-02 | — | — | EP | disclosed |