Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2525180 | 0.84 | NPSR1 (0.36) | KMT2ASMN1; SMN2MAPTATMTDP1 | |
| SCHEMBL3732991 | 0.83 | ALDH1A1 (0.32) | KMT2ASMN1; SMN2MAPTATMTDP1 | |
| SCHEMBL6290176 | 0.82 | MEN1 (0.35) | KMT2AMEN1NPSR1ALDH1A1POLB | |
| SCHEMBL4501238 | 0.79 | ALDH1A1 (0.35) | KMT2ASMN1; SMN2MAPTATMTDP1 | |
| SCHEMBL2947752 | 0.79 | EPHX2 (0.34) | EPHX2 | |
| SCHEMBL728293 | 0.75 | ALDH1A1 (0.34) | KMT2ASMN1; SMN2MAPTATMTDP1 | |
| SCHEMBL2433660 | 0.72 | TSHR (0.36) | KMT2ASMN1; SMN2MAPTTDP1MEN1 | |
| SCHEMBL1153522 | 0.72 | MEN1 (0.39) | KMT2ASMN1; SMN2MAPTMEN1ALDH1A1 | |
| SCHEMBL16463001 | 0.70 | OPRM1 (0.36) | KMT2ASMN1; SMN2MAPTMEN1TSHR | |
| SCHEMBL30754254 | 0.68 | TSHR (0.46) | KMT2ASMN1; SMN2MAPTATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314254-B2 | Substituted spirocyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2012-11-20 | — | — | US | disclosed |
| US-20100234229-A1 | Substituted Spirocyclic Ketoenols | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| US-7754654-B2 | Substituted spirocyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2010-07-13 | — | — | US | disclosed |
| US-20070275858-A1 | SUBSTITUTED SPIROCYCLIC KETOENOLS | BAYER CROPSCIENCE AG (DE) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275858-A1 | SUBSTITUTED SPIROCYCLIC KETOENOLS | PDHX, CYP19A1, AKR1A1 | KMT2A 1581/4885SMN1; SMN2 4513/4885MAPT 4691/4885 |
| US-20100234229-A1 | Substituted Spirocyclic Ketoenols | HSD17B7, CYP17A1, HSD17B11 | KMT2A 2230/4885SMN1; SMN2 4555/4885MAPT 4651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.